ArticlePLoS genetics2017
Northeast African genomic variation shaped by the continuity of indigenous groups and Eurasian migrations.
Article in PLoS genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- HLA alleles and haplotypes in Sudanese population and their relationship with Mediterraneans.Scientific reports · 2023Pooled it
- Human genetic ancestry,eLife · 2026Article
- Sudan's complex genetic admixture history drives adaptation to malaria in Sudanese Copts.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Tracing human genetic histories and natural selection with precise local ancestry inference.Nature communications · 2025Article
- Clinical phenotyping and genetic diagnosis of a large cohort of Sudanese families with hereditary spinocerebellar degenerations.European journal of human genetics : EJHG · 2024Article
- Whole genomes from Angola and Mozambique inform about the origins and dispersals of major African migrations.Nature communications · 2023Article
- Evolutionary Genetics and Admixture in African Populations.Genome biology and evolution · 2023Review
- Dense sampling of ethnic groups within African countries reveals fine-scale genetic structure and extensive historical admixture.Science advances · 2023Article
- Review
- Eurasian back-migration into Northeast Africa was a complex and multifaceted process.PloS one · 2023Article
- Demographic and Selection Histories of Populations Across the Sahel/Savannah Belt.Molecular biology and evolution · 2022Article
- Genetic structure correlates with ethnolinguistic diversity in eastern and southern Africa.American journal of human genetics · 2022Article
- Genomic analysis reveals geography rather than culture as the predominant factor shaping genetic variation in northern Kenyan human populations.American journal of biological anthropology · 2022Article
- Hunter-gatherer genomes reveal diverse demographic trajectories during the rise of farming in Eastern Africa.Current biology : CB · 2022Article
- Social stratification without genetic differentiation at the site of Kulubnarti in Christian Period Nubia.Nature communications · 2021Article
- Contrasting epidemiology and genetic variation of Plasmodium vivax infecting Duffy-negative individuals across Africa.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021Article
- The deep population history in Africa.Human molecular genetics · 2021Review
- Genetic diversity of the Sudanese: insights on origin and implications for health.Human molecular genetics · 2021Review
- Estimating divergence times from DNA sequences.Genetics · 2021Article
- The Landscape of Micro-Inversions Provide Clues for Population Genetic Analysis of Humans.Interdisciplinary sciences, computational life sciences · 2020Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Northeast Africa has a long history of human habitation, with fossil-finds from the earliest anatomically modern humans, and housing ancient civilizations. The region is also the gate-way out of Africa, as well as a portal for migration into Africa from Eurasia via the Middle East and the Arabian Peninsula. We investigate the population history of northeast Africa by genotyping ~3.9 million SNPs in 221 individuals from 18 populations sampled in Sudan and South Sudan and combine this data with published genome-wide data from surrounding areas. We find a strong genetic divide between the populations from the northeastern parts of the region (Nubians, central Arab populations, and the Beja) and populations towards the west and south (Nilotes, Darfur and Kordofan populations). This differentiation is mainly caused by a large Eurasian ancestry component of the northeast populations likely driven by migration of Middle Eastern groups followed by admixture that affected the local populations in a north-to-south succession of events. Genetic evidence points to an early admixture event in the Nubians, concurrent with historical contact between North Sudanese and Arab groups. We estimate the admixture in current-day Sudanese Arab populations to about 700 years ago, coinciding with the fall of Dongola in 1315/1316 AD, a wave of admixture that reached the Darfurian/Kordofanian populations some 400-200 years ago. In contrast to the northeastern populations, the current-day Nilotic populations from the south of the region display little or no admixture from Eurasian groups indicating long-term isolation and population continuity in these areas of northeast Africa.
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