ArticlePloS one2017
Septic shock and the use of norepinephrine in an intermediate care unit: Mortality and adverse events.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Incidence of Adverse Events in Peripheral Intravenous Vasopressor Use: A Systematic Review and Meta-Analysis.JAMA network open · 2026Pooled it
- Adverse events associated with administration of vasopressor medications through a peripheral intravenous catheter: a systematic review and meta-analysis.Critical care (London, England) · 2021Pooled it
- Restricted fluid resuscitation in suspected sepsis associated hypotension (REFRESH): a pilot randomised controlled trial.Intensive care medicine · 2018Trial
- Effect of timing of norepinephrine administration on prognosis of patients with septic shock: A prospective cohort study.Journal of intensive medicine · 2025Article
- Impact of Noradrenaline Administration Dosage on the Occurrence of Peripheral Intravenous Catheter-Related Venous Phlebitis in Critically Ill Patients Using a Time-Dependent Multilevel Cox Regression Model.Emergency medicine international · 2025Article
- Review
- Long-Term Outcome of Critically Ill Advanced Cancer Patients Managed in an Intermediate Care Unit.Journal of clinical medicine · 2022Article
- Norepinephrine with dopamine infusion on the end-tidal carbon dioxide (ETco2) pressure in patients with septic shock.Caspian journal of internal medicine · 2021Article
- Performance of Critical Care Outcome Prediction Models in an Intermediate Care Unit.Journal of intensive care medicine · 2020Article
- Feasibility and safety of angiotensin II administration in general ward patients during COVID-19 pandemic: a case series.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2020Article
- [Perioperative pharmacological circulatory support in daily clinical routine].Der Anaesthesist · 2020Review
- Norepinephrine in septic shock.Intensive care medicine · 2019Article
- Sepsis associated acute kidney injury.BMJ (Clinical research ed.) · 2019Review
- Hospital mortality prediction for intermediate care patients: Assessing the generalizability of the Intermediate Care Unit Severity Score (IMCUSS).Journal of critical care · 2018Article
- Expert statement for the management of hypovolemia in sepsis.Intensive care medicine · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeptic shock is associated with high mortality. Aged and multimorbid patients are not always eligible for intensive care units. Norepinephrine is an accepted treatment for hypotension in septic shock. It is unknown whether norepinephrine has a place in treatment outside an intensive care unit and when given peripherally.
objectivesTo describe mortality, Acute Physiology And Chronic Health Evaluation (APACHE-II), time to mean arterial pressure >65 mmHg, and adverse events in patients with septic shock receiving norepinephrine peripherally in an intermediate care unit.
methodsFrom a retrospective chart review of 91 patients with septic shock treated with norepinephrine for hypotension, ward mortality, 30-, 60- and 90-day mortality, standardized mortality ratio (SMR) and adverse events (necrosis and arrhythmia) were analysed. Administration route via peripheral venous catheter or central venous catheter was registered.
resultsMedian age was 81 (43-96) years and median APACHE-II score was 26 (12-42). Observed ward mortality was 27.5% (SMR 0.443, 95% CI: 0.287-0.654), and 30-day and 90-day mortality were 47.2% and 58.2%, respectively.
conclusionsElderly patients with septic shock treated with norepinephrine displayed a better survival in the ward and at 30 days than expected. Our retrospective study did not indicate frequent complications when administering norepinephrine via a peripheral venous catheter.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.