Evidence map›Paper›PMID 28837393›Full record

ReviewTissue barriers2017

Claudins in morphogenesis: Forming an epithelial tube.

Amanda I Baumholtz, Indra R Gupta, Aimee K Ryan

Open access · bronzeAbstract readReview
In one paragraph

Review in Tissue barriers, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Tight junction structure, assembly and (dys)function.Nature reviews. Molecular cell biology · 2026
    Review
  3. Review
  4. Epithelia Are Scaffolds for Electricity-Dependent Molecular Interactions.Reviews of physiology, biochemistry and pharmacology · 2025
    Review
  5. Sur7 mediates a novel pathway for PIMolecular biology of the cell · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Building barriers.Tissue barriers · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Amanda I Baumholtza Department of Human Genetics , McGill University , Montréal , Québec , Canada.
Indra R Guptaa Department of Human Genetics , McGill University , Montréal , Québec , Canada.
Aimee K Ryana Department of Human Genetics , McGill University , Montréal , Québec , Canada.
McGill University Health Centre · CAMcGill University · CA

Funding

CIHR
6 · The paper itself

Abstract

The claudin family of tetraspan transmembrane proteins is essential for tight junction formation and regulation of paracellular transport between epithelial cells. Claudins also play a role in apical-basal cell polarity, cell adhesion and link the tight junction to the actin cytoskeleton to exert effects on cell shape. The function of claudins in paracellular transport has been extensively studied through loss-of-function and gain-of-function studies in cell lines and in animal models, however, their role in morphogenesis has been less appreciated. In this review, we will highlight the importance of claudins during morphogenesis by specifically focusing on their critical functions in generating epithelial tubes, lumens, and tubular networks during organ formation.

Indexed as

AnimalsClaudinsEpitheliumHumansMorphogenesisClaudinsanimal modelclaudinepithelial tubulogenesislumenmorphogenesisneural tubetight junction

Identifiers

PMID28837393
PMCPMC5788437
OpenAlexW2740562437

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.