ReviewMolecules (Basel, Switzerland)2017
Looking Back, Looking Forward at Halogen Bonding in Drug Discovery.
Review in Molecules (Basel, Switzerland), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
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Who cites it
68 citing papers in PubMed.
- Chemoselective halogenation of premarineosin A for next-generation antimalarial development.Organic & biomolecular chemistry · 2026Article
- Synthesis and Binding Affinity Insights of 2-Phenyl-1H-Benzimidazole Inhibitors Targeting FTO by Spectroscopic Characterization and Molecular Docking.Journal of molecular recognition : JMR · 2026Article
- Article
- Chloride-Selective Transmembrane Channel Formation byJACS Au · 2026Article
- AI-Enabled Mapping of Structure-Hazard Relationships for Emerging Contaminants.Environment & health (Washington, D.C.) · 2026Article
- Molecular Electrostatic Surface Potential: A Predictive Framework for Noncovalent Interactions and Adsorption Characteristics in Molecular Entities.International journal of molecular sciences · 2026Review
- A Structure-activity Relationship (SAR) Insight for the Most Effective Oral Antidiabetic Compounds-A Current Review.Current topics in medicinal chemistry · 2026Review
- Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A.Communications chemistry · 2025Article
- First-Principles Modeling of Nitazoxanide Analogues as Prospective PFOR-Targeted Antibacterials.International journal of molecular sciences · 2025Article
- Matere bond identification in non-crystalline materials by using X-ray photoelectron spectroscopy.Chemical science · 2025Article
- Synthesis and Conformational Analysis of Pyran Interhalide Analogues of Galactose, Mannose, Talose, and Glucose.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- Structure-activity analysis of imino-pyrimidinone-fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors.The FEBS journal · 2025Article
- Decrypting the Unusual Structure and σ-Hole Interactions of the XC(NOMolecules (Basel, Switzerland) · 2025Article
- LAGNet: better electron density prediction for LCAO-based data and drug-like substances.Journal of cheminformatics · 2025Article
- Thyroid Hormone Deiodination-Mechanisms and Small Molecule Enzyme Mimics.Biomolecules · 2025Review
- Polarization Upends Convention: Halogen Bonding Propensities of Main Group Halides.The journal of physical chemistry. A · 2025Article
- Unique halogen-π association detected in single crystals of C-N atropisomericBeilstein journal of organic chemistry · 2025Article
- Bromo- and chloro-substituted flavones induce apoptosis and modulate cell death pathways in canine lymphoma and leukemia cells - a comparativeFrontiers in molecular biosciences · 2025Article
- DrugDAGT: a dual-attention graph transformer with contrastive learning improves drug-drug interaction prediction.BMC biology · 2024Article
- Unconventional Radical and Radical-Hole Site-Based Interactions in Halogen-Bearing Dimers and Trimers: A Comparative Study.ACS omega · 2024Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Halogen bonding has emerged at the forefront of advances in improving ligand: receptor interactions. In particular the newfound ability of this extant non-covalent-bonding phenomena has revolutionized computational approaches to drug discovery while simultaneously reenergizing synthetic approaches to the field. Here we survey, via examples of classical applications involving halogen atoms in pharmaceutical compounds and their biological hosts, the unique advantages that halogen atoms offer as both Lewis acids and Lewis bases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.