SynthesisJBRA assisted reproduction2017
Are children born from singleton pregnancies conceived by ICSI at increased risk for congenital malformations when compared to children conceived naturally? A systematic review and meta-analysis.
Synthesis in JBRA assisted reproduction, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Environmental and Genetic Risk Factors of Congenital Anomalies: an Umbrella Review of Systematic Reviews and Meta-Analyses.Journal of Korean medical science · 2021Pooled it
- The effect of ICSI in infertility couples with non-male factor: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2020Pooled it
- The Genetics of Female and Male Infertility.Deutsches Arzteblatt international · 2025Review
- Reproductive genetics and health.Medizinische Genetik : Mitteilungsblatt des Berufsverbandes Medizinische Genetik e.V · 2024Article
- Trends in the incidence of major birth defects after assisted reproductive technologies in Lombardy Region, Northern Italy.Journal of assisted reproduction and genetics · 2023Article
- Brain malformations in diprosopia observed in clinical cases, museum specimens and artistic representations.Orphanet journal of rare diseases · 2023Article
- Evaluation of Bone Mineral Density in Children ConceivedFrontiers in endocrinology · 2022Article
- ISAR Consensus Guidelines on Add-Ons Treatment inJournal of human reproductive sciences · 2021Article
- Laser-assisted selection of immotile spermatozoa has no effect on obstetric and neonatal outcomes of TESA-ICSI pregnancies.Reproductive biology and endocrinology : RB&E · 2021Article
- Genetic Factors of Non-Obstructive Azoospermia: Consequences on Patients' and Offspring Health.Journal of clinical medicine · 2021Review
- Genetic counseling prior to assisted reproductive technology.Reproductive medicine and biology · 2021Review
- A bespoke data linkage of an IVF clinical quality registry to population health datasets; methods and performance.International journal of population data science · 2021Article
- Assessment of operant learning and memory in mice born through ICSI.Human reproduction (Oxford, England) · 2020Article
- Genetic counseling prior to Assisted Reproductive Technology procedures in the era of cytogenomics.JBRA assisted reproduction · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since 1992, the development of intra-cytoplasmic sperm injection (ICSI) has allowed infertile couples and couples affected by severe male factor infertility in particular, many of which with a history of failed traditional IVF, to become parents. This has generated considerable controversy over the safety of the procedure for the offspring. This systematic review seeks to determine whether evidence indicates that the use of ICSI increases the risk of congenital malformation in children born from singleton pregnancies versus naturally conceived children. Twenty-one of the 104 publications listed in the literature search were included in the analysis. Observational studies reported mostly an increased risk for congenital malformation; the risk of congenital malformations is 7.1% in ICSI and 4.0% in the general population (OR 1.99 (95% CI [1.87 - 2.11]). However, attributing higher risk solely to ICSI might seem far-fetched, as in vitro and simulation procedures, patient diseases, and ICSI indication may also be associated with higher risk of malformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.