Evidence map›Paper›PMID 28836675›Full record

ArticleJournal of child psychology and psychiatry, and allied disciplines2017

Commentary: The importance of exploring dose-dependent, subtype-specific, and age-related effects of maltreatment on the HPA axis and the mediating link to psychopathology. A response to Fisher (2017).

Lars O White, Marcus Ising, Kai von Klitzing, Susan Sierau, Andrea Michel, Annette M Klein, Bertram Müller-Myhsok, Manfred Uhr, Michael J Crowley, Clemens Kirschbaum and 1 more

Abstract readComment
PubMed Publisher
In one paragraph

Article in Journal of child psychology and psychiatry, and allied disciplines, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Lars O WhiteDepartment of Child and Adolescent Psychiatry, University of Leipzig, Leipzig, Germany.
Marcus IsingMax Planck Institute of Psychiatry, Munich, Germany.
Kai von KlitzingDepartment of Child and Adolescent Psychiatry, University of Leipzig, Leipzig, Germany.
Susan SierauDepartment of Child and Adolescent Psychiatry, University of Leipzig, Leipzig, Germany.
Andrea MichelDepartment of Child and Adolescent Psychiatry, University of Leipzig, Leipzig, Germany.
Annette M KleinDepartment of Child and Adolescent Psychiatry, University of Leipzig, Leipzig, Germany.
Bertram Müller-MyhsokMax Planck Institute of Psychiatry, Munich, Germany.
Manfred UhrMax Planck Institute of Psychiatry, Munich, Germany.
Michael J CrowleyYale Child Study Center, Yale University School of Medicine, New Haven, CT, USA.
Clemens KirschbaumInstitute of Psychology, TU Dresden, Dresden, Germany.
Tobias StalderInstitute of Psychology, TU Dresden, Dresden, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We greatly appreciate Dr. Fisher's commentary that provides an excellent backdrop and well-considered perspective on our findings. We agree that our results mesh well with previous work documenting hypocortisolism among youth who experienced early adversity, especially neglect. Moreover, as also perceptively noted by Dr. Fisher, our cross-sectional data provide support for the notion that hypocortisolism is not simply a transient phenomenon, but, rather, a persistent pattern characterizing maltreated youth. Specifically, the consistency of the between group effect (from age 9.69 onwards) on a multimonth index of cumulative cortisol and the dose-dependent gradient of cortisol secretion within the maltreated group, which was related to the number of subtypes and the length of exposure to maltreatment, lend weight to this view.

Indexed as

Child AbuseHydrocortisoneAdolescentChildCross-Sectional StudiesHairHumansHypothalamo-Hypophyseal SystemPituitary-Adrenal SystemPsychopathologyHydrocortisoneMaltreatmentpsychopathology

Identifiers

PMID28836675

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.