ArticleProceedings of the National Academy of Sciences of the United States of America1987
Genomic and cDNA actin sequences from a virulent strain of Entamoeba histolytica.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1987. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 90 citations in OpenAlex.
- Advances inFrontiers in microbiology · 2019Review
- The Entamoeba histolytica TBP and TRF1 transcription factors are GAAC-box binding proteins, which display differential gene expression under different stress stimuli and during the interaction with mammalian cells.Parasites & vectors · 2018Article
- The cell cycle of Entamoeba histolytica.Molecular and cellular biochemistry · 2003Review
- The invasiveness of Entamoeba histolytica - a continuing enigma.Clinical molecular pathology · 1996Article
- Entamoeba histolytica trophozoites induce an inflammatory cytokine response by cultured human cells through the paracrine action of cytolytically released interleukin-1 alpha.The Journal of clinical investigation · 1995Article
- Transfection and transient expression of chloramphenicol acetyltransferase gene in the protozoan parasite Entamoeba histolytica.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Sequence analysis of duplicated actin genes in Lagenidium giganteum and Pythium irregulare (Oomycota).Journal of molecular evolution · 1994Article
- Similarity between a ubiquitous promoter element in an ancient eukaryote and mammalian initiator elements.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- A variable DNA region of Entamoeba histolytica is expressed in several transcripts which differ in genetically related clones.Molecular & general genetics : MGG · 1993Article
- Electrophoretic karyotype and chromosome assignments for a pathogenic and a nonpathogenic strain of Entamoeba histolytica.Infection and immunity · 1993Article
- Cloning of a virulence factor of Entamoeba histolytica. Pathogenic strains possess a unique cysteine proteinase gene.The Journal of clinical investigation · 1993Article
- Beta-succinyl-coenzyme A synthetase from Trichomonas vaginalis is a soluble hydrogenosomal protein with an amino-terminal sequence that resembles mitochondrial presequences.Journal of bacteriology · 1992Article
- Codon usage in pathogenic Entamoeba histolytica.Journal of molecular evolution · 1992Article
- Molecular phylogenetic analysis of actin genic regions from Achlya bisexualis (Oomycota) and Costaria costata (Chromophyta).Journal of molecular evolution · 1991Article
- The biology of Giardia spp.Microbiological reviews · 1991Review
- Sequence of a cysteine-rich galactose-specific lectin of Entamoeba histolytica.Proceedings of the National Academy of Sciences of the United States of America · 1991Article
- Isolation of a strain-specific Entamoeba histolytica cDNA clone.Journal of clinical microbiology · 1991Article
- Characterization of an immuno-dominant variable surface antigen from pathogenic and nonpathogenic Entamoeba histolytica.The Journal of experimental medicine · 1990Article
- cDNA sequence analysis of a 29-kDa cysteine-rich surface antigen of pathogenic Entamoeba histolytica.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
- Molecular analysis of the hydrogenosomal ferredoxin of the anaerobic protist Trichomonas vaginalis.Proceedings of the National Academy of Sciences of the United States of America · 1990Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Invasiveness of Entamoeba histolytica strains that cause acute amoebiasis is characterized by aggressive behavior associated with cell motility and actin function. Analysis of actin genes from E. histolytica was initiated by devising methods for the isolation of biologically active nucleic acids, which allowed the preparation of cDNA and genomic DNA libraries. E. histolytica actin-encoding cDNAs and genomic clones have been isolated from libraries prepared from the virulent HM1:IMSS strain using a heterologous actin probe. Nucleotide sequence analysis of three independent cDNA clones and one genomic clone reveals a highly unusual codon bias and the absence of intervening sequences in E. histolytica actin. The coding sequence of the genomic clone is identical to that of two of the three cDNA clones. These represent at least two distinct mRNAs differing only by five silent changes in the protein coding sequence. Multiple genomic copies of the actin gene can be detected by Southern hybridization. E. histolytica actin exhibits a higher degree of homology to cytoplasmic than to muscle actin. Although the protein has been shown not to bind DNase I, the inferred amino acid sequence indicates conservation of all residues implied to participate in this binding.
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