ArticleEndoscopic ultrasound
A prospective study of endoscopic ultrasonography features, cyst fluid carcinoembryonic antigen, and fluid cytology for the differentiation of small pancreatic cystic neoplasms.
Article in Endoscopic ultrasound. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Stereomicroscopic on-site evaluation in endoscopic ultrasound-guided tissue acquisition of upper gastrointestinal subepithelial lesions.Clinical endoscopy · 2024Article
- Glycopatterns and Glycoproteins Changes in MCN and SCN: A Prospective Cohort Study.BioMed research international · 2019Article
- Pancreatic cystic neoplasms in 2018: The final cut.Endoscopic ultrasoundArticle
- Rapid on-site evaluation (ROSE) with EUS-FNA: The ROSE looks beautiful.Endoscopic ultrasoundArticle
- Intraductal papillary mucinous neoplasms from a pancreas rest (with video).Endoscopic ultrasoundArticle
- An international, multi-institution survey of the use of EUS in the diagnosis of pancreatic cystic lesions.Endoscopic ultrasoundArticle
- Evaluation of a new slim radial echoendoscope: A better option for an aging population.Endoscopic ultrasoundArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
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Abstract
BACKGROUND AND
objectivesWith improvements in imaging technologies, pancreatic cystic lesions (PCLs) have been increasingly identified in recent years. However, the imaging modalities used to differentiate the categories of pancreatic cysts remain limited, which may cause confusion when planning treatment. Due to progress in endoscopic ultrasonography-guided fine-needle aspiration (EUS-FNA) technology, auxiliary diagnosis by the detection of cystic fluid has become a recent trend.
methodsFrom March 2015 to April 2016, 120 patients with PCLs were enrolled in this study. According to the results of EUS, cyst fluid carcinoembryonic antigen (CEA) analysis, and cystic fluid cytology, the patients were divided into two groups: a nonmucinous and a mucinous group. Of those, 61 patients who had undergone surgical resection were included in the analysis. The clinical features, biochemical and tumor markers of cyst fluid as well as the cytological test results of the patients were compared with histopathology results.
resultsA cyst size of 4.0 cm was used as the boundary value; a cyst ≤4.0 cm was defined as a small PCL. 87 (72.5%) lesions were ≤4.0 cm, and 33 (27.5%) lesions were >4.0 cm. Regarding the analysis of CEA and carbohydrate antigens 19-9 (CA19-9), significant differences were found between the nonmucinous and mucinous groups (P < 0.05) according to nonparametric independent samples tests. The EUS, cystic fluid CEA, and cystic fluid cytology results were compared with the tissue pathology findings using McNemar's test (P < 0.05) and showed a sensitivity of 90% and a specificity of 84%.
conclusionA diagnostic combination of EUS, cyst fluid CEA, and cystic fluid cytology could be used to differentiate small pancreatic cystic neoplasms. Cystic fluid cytology analysis is helpful for planning treatment for pancreatic cystic tumors that pose a surgical risk.
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