Evidence map›Paper›PMID 28836492›Full record

SynthesisPublic health nutrition2017

Association of vegetarian diet with inflammatory biomarkers: a systematic review and meta-analysis of observational studies.

Fahimeh Haghighatdoost, Nick Bellissimo, Julia O Totosy de Zepetnek, Mohammad Hossein Rouhani

Registry-linked trialAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Public health nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07728877 (A Culture-tailored Plant-based Dietary Intervention in Taiwan), which is not on this map. Cited by 79 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed, 12 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07728877 nacompletednot on this mapstarted 2023, after this paper: background citation

A Culture-tailored Plant-based Dietary Intervention in Taiwan: A Pilot Randomized Crossover Feasibility Trial With Preliminary Inflammatory and Metabolic Outcomes

TypeinterventionalSponsorTzu Chi UniversityRan2023 to 2023Enrolled30ConditionsHealthy, Dietary HabitsArmsPlant-Based Diet, General Diet
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 12 syntheses or guidelines pooled it.

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  10. Vegetarian and Vegan Diet in Fibromyalgia: A Systematic Review.International journal of environmental research and public health · 2021
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  15. Assessing the effects of alternative plant-based meatsJournal of nutritional science · 2022
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fahimeh Haghighatdoost1Food Security Research Center,Isfahan University of Medical Sciences,Hezar Jarib Street, PO Box 81745, Isfahan,Islamic Republic of Iran.
Nick Bellissimo3School of Nutrition,Ryerson University,Toronto,Ontario,Canada.
Julia O Totosy de Zepetnek3School of Nutrition,Ryerson University,Toronto,Ontario,Canada.
Mohammad Hossein Rouhani1Food Security Research Center,Isfahan University of Medical Sciences,Hezar Jarib Street, PO Box 81745, Isfahan,Islamic Republic of Iran.ORCID http://orcid.org/0000-0003-2451-0083

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveVegetarian diets contain various anti-inflammatory components. We aimed to investigate the effects of vegetarianism on inflammatory biomarkers when compared with omnivores.

designSystematic review and meta-analysis.

settingLiterature search was conducted in Science Direct, Proquest, MEDLINE and Google Scholar up to June 2016. Summary estimates and corresponding 95 % CI were derived via the DerSimonian and Laird method using random effects, subgroup analyses were run to find the source of heterogeneity and a fixed-effect model examined between-subgroup heterogeneity. SUBJECTS: Studies were included if they evaluated effects of any type of vegetarianism compared with omnivores on circulating levels of inflammatory biomarkers. No restriction was made in terms of language or the date of study publications.

resultsEighteen articles were included. Pooled effect size showed no difference in high-sensitivity C-reactive protein (hs-CRP) levels in vegetarians v. omnivores (Hedges' g=-0·15; 95 % CI -0·35, 0·05), with high heterogeneity (I 2=75·6 %, P<0·01). A subgroup analysis by minimum duration of vegetarianism showed that a minimum duration of 2 years vegetarianism was associated with lower hs-CRP levels v. omnivores (Hedges' g=-0·29; 95 % CI -0·59, 0·01), with moderate heterogeneity (I 2=68·9 %, P<0·01). No significant effect was found in studies using a minimum duration of 6 months of vegetarianism, with low heterogeneity. Vegetarianism was associated with increased IL-6 concentrations (0·21 pg/ml; 95 % CI 0·18, 0·25), with no heterogeneity (I 2=0·0 %, P=0·60).

conclusionsThe meta-analysis provides evidence that vegetarianism is associated with lower serum concentrations of hs-CRP when individuals follow a vegetarian diet for at least 2 years. Further research is necessary to draw appropriate conclusions regarding potential associations between vegetarianism and IL-6 levels. A vegetarian diet might be a useful approach to manage inflammaging in the long term.

Indexed as

Diet, VegetarianBiomarkersC-Reactive ProteinHumansInflammationInterleukin-6Non-Randomized Controlled Trials as TopicObservational Studies as TopicSensitivity and SpecificityBiomarkersC-Reactive ProteinIL6 protein, humanInterleukin-6C-reactive proteinIL-6InflammationOmnivoresVegetarianism

Identifiers

PMID28836492
PMCPMC10261540

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.