Evidence map›Paper›PMID 28836277›Full record

ArticleInternational journal of cancer2017

The risk of preterm birth and growth restriction in pregnancy after cancer.

Kathleen P Hartnett, Kevin C Ward, Michael R Kramer, Timothy L Lash, Ann C Mertens, Jessica B Spencer, Amy Fothergill, Penelope P Howards

Open access · bronzeAbstract read
In one paragraph

Article in International journal of cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.

  1. Pooled it
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  7. Joint effects of IVF and cancer history on birth outcomes.Journal of assisted reproduction and genetics · 2026
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  12. A Scoping Review of Preterm Birth Risk Factors.American journal of perinatology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Kathleen P HartnettDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.ORCID 0000-0001-5774-8966
Kevin C WardDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Michael R KramerDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Timothy L LashDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Ann C MertensAflac Cancer Center, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA.
Jessica B SpencerDepartment of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA.
Amy FothergillDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Penelope P HowardsDepartment of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA.
Emory University · US

Funding

TENNESSEE MATIONAL CANCER PREVENTION & CONTROL PROGRAM, INCLUDING CANCER REGISTRYU58DP003901 · DP · TENNESSEE STATE DEPARTMENT OF HEALTH · PI WHITESIDE, MARTIN · 2012 to 2014
$7.0M
A Population-Based Study of Fertility in Female Survivors of Young Adult CancerR01HD066059 · NICHD · EMORY UNIVERSITY · PI HOWARDS, PENELOPE P. · 2010 to 2014
$3.1M
Training in Reproductive, Perinatal, Pediatric EpidemiologyT32HD052460 · NICHD · EMORY UNIVERSITY · PI DREWS-BOTSCH, CAROLYN DAWSON · 2006 to 2015
$2.2M
CCR NIH HHS HHSN261201300015CNCCDPHP CDC HHS U58 DP003901NICHD NIH HHS R01 HD066059NICHD NIH HHS T32 HD052460
6 · The paper itself

Abstract

It is unclear whether cancer and its treatments increase the risk of adverse pregnancy outcomes. Our aim was to examine whether cancer survivors have higher risks of poor outcomes in pregnancies conceived after diagnosis than women without cancer, and whether these risks differ by cancer type and race. Diagnoses from cancer registries were linked to pregnancy outcomes from birth certificates in three U.S. states. Analyses were limited to the first, live singleton birth conceived after diagnosis. Births to women without a previous cancer diagnosis in the registry were matched to cancer survivors on age at delivery, parity, race/ethnicity and education. Log-binomial regression was used to estimate risk ratios. Cervical cancer survivors had higher risks of preterm birth (Risk ratio = 2.8, 95% Confidence interval: 2.1, 3.7), as did survivors of invasive breast cancer (RR = 1.3, 95% CI: 1.1, 1.7) and leukemia (RR = 2.1, 95% CI: 1.3, 3.5). We observed a higher risk of small for gestational age (SGA) infants (<10% of weight for age based on a national distribution) in survivors of brain cancer (RR = 1.7, 95% CI: 1.1, 2.8) and extranodal non-Hodgkin lymphoma (RR = 2.3, 95% CI: 1.5, 3.6). We did not see an increased risk of infants born preterm, low birth weight, or SGA in pregnancies conceived after ductal carcinoma in situ, thyroid cancer, melanoma, or Hodgkin lymphoma. While our results are reassuring for survivors of many cancers, some will need closer monitoring during pregnancy.

Indexed as

AdultFemaleFetal Growth RetardationHumansMiddle AgedNeoplasmsOdds RatioPregnancyPremature BirthRegistriesSurvivorsYoung Adultbirth outcomecancer survivorpregnancy

Identifiers

PMID28836277
PMCPMC5766343
OpenAlexW2747917830

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.