ArticleHigh blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension2017
The Role of Brachial Pulse Pressure as an Indicator of Intracranial Atherosclerosis: The Atahualpa Project.
Article in High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- The Carotid Siphon as a Pulsatility Modulator for Brain Protection: Role of Arterial Calcification Formation.Journal of personalized medicine · 2025Review
- Incidental Calcifications of Carotid and Vertebral Arteries: Frequency and Associations in Pediatric Population.Diagnostics (Basel, Switzerland) · 2025Article
- Current knowledge of large vascular occlusion due to intracranial atherosclerosis: focusing on early diagnosis.Chinese neurosurgical journal · 2020Review
- Rapid Systolic Blood Pressure Changes After Standing Up Associate With Impaired Physical Performance in Geriatric Outpatients.Journal of the American Heart Association · 2018Article
- Association Between Pulsatile Components of Blood Pressure and Severe Tooth Loss in Rural Ecuador: The Three Villages Study.Journal of primary care & community healthArticle
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionCarotid siphon calcifications (CSC) are an important imaging marker of systemic atherosclerosis. Routine assessment of asymptomatic CSC may allow the implementation of intervention strategies before catastrophic cerebrovascular events occur.
aimTo assess whether brachial PP determinations might independently predicts the presence and severity of CSC in community-dwelling adults.
methodsAll Atahualpa residents aged ≥40 years were invited for the practice of a non-enhanced CT scan of the head, and those who signed the informed consent and had no contraindications for this exam were enrolled. The brachial PP was calculated by subtracting the mean diastolic pressure from the mean systolic pressure obtained from three different readings with individuals in the sitting position.
resultsOf 830 eligible candidates, 663 (80%) were included. The mean brachial PP was 56.4 ± 19.9 mmHg; 182 persons (27.4%) had PP levels >65 mmHg. CT revealed Grade 1 CSC in 356 (54%), Grade 2 in 141 (21%), Grade 3 in 128 (19%), and Grade 4 in 38 (6%) subjects. Predictive margins of PP (delta method) were significantly lower in individuals with Grade 1 CSC than in the other groups. In the best adjusted linear model, PP levels increased up to 11.7 mmHg as the severity of CSC increased (β 11.71; 95% C.I. 5.36-18.08: p < 0.001).
conclusionThis study provides evidence on the relationship between brachial PP levels and intracranial atherosclerosis. Calculation of the PP may be used for detecting candidates for CT screening, reducing costs during population-based surveys, particularly in remote areas.
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