ArticleJournal of neural transmission (Vienna, Austria : 1996)2017
Is nigrostriatal dopaminergic deficit necessary for Holmes tremor to develop? The DaTSCAN and IBZM SPECT study.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping holmes tremor circuit using the human brain connectome.Annals of neurology · 2019Pooled it
- Neurophysiological Basis of Tremor Disorders: Parkinson's Disease, Essential Tremor, Tremor in Dystonia, and Holmes Tremor.Seminars in neurology · 2026Review
- Effective radiofrequency thalamotomy for posttraumatic Holmes tremor: illustrative case.Journal of neurosurgery. Case lessons · 2026Article
- Tremor pathophysiology.Clinical parkinsonism & related disorders · 2026Review
- Amantadine Toxicity Mimicking Holmes Tremor Following Diuretic Dose Escalation: A Case Report.Cureus · 2026Article
- Delayed Holm's tremor complicated by contralateral midbrain metastasis: A nigrostriatal subtype.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- The role of presynaptic dopaminergic imaging in acquired neurological conditions affecting basal ganglia: a systematic review.Frontiers in neurology · 2025Review
- Analysis of Semiology, Lesion Topography and Treatment Outcomes: A Prospective Study on Post Thalamic Stroke Holmes Tremor.Journal of movement disorders · 2024Article
- Clinical Features, Neuroimaging, and Levodopa-Responsiveness in Holmes' Tremor: A Video-Based Case-Series with a Review of the Literature.Movement disorders clinical practice · 2022Review
- An Argument in Favor of Deep Brain Stimulation for Uncommon Movement Disorders: The Case for N-of-1 Trials in Holmes Tremor.Frontiers in human neuroscience · 2022Article
- Study on the pathogenesis of Holmes tremor by multimodal 3D medical imaging: case reports of three patients.BMC neurology · 2021Article
- The Molecular Neuroimaging of Tremor.Current neurology and neuroscience reports · 2021Review
- Thalamic versus midbrain tremor; two distinct types of Holmes' Tremor: a review of 17 cases.Journal of neurology · 2021Article
- Damage to the central nucleus of the thalamus via atypical Holmes tremor: a case report.The Journal of international medical research · 2021Article
- Reversible Holmes Tremor due to Middle Cerebral Artery Giant Aneurysm.Tremor and other hyperkinetic movements (New York, N.Y.) · 2019Article
- The Temporal Course of the MRI Findings of Inferior Oliver Hypertrophy: The Clinicoradiologic Presentation of a Rare Patient with Holmes Tremor and Palatal Myoclonus.Annals of Indian Academy of NeurologyArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Holmes's tremor (HT) is assumed to be the result of coexistence of nigrostriatal dopaminergic system impairment and the lesion of cerebello-thalamic pathways. It was suggested that dopaminergic deficiency is responsible for rest tremor, and lack of compensatory cerebellar function leads to spill of tremor into voluntary movements. Cases of HT with and without abnormalities of the presynaptic part of dopaminergic nigrostriatal were published and these findings raised the question of possibility of the postsynaptic lesion. Three patients with HT diagnosed according to criteria of Consensus Statement on Tremor were studied. In all of them SPECT imaging with ligands of presynaptic (I 123-FP CIT-DaTSCAN) and postsynaptic (I 123-iodobenzamide-IBZM) nigrostriatal dopaminergic neurons was performed. Indices of uptake in caudate and putamen normalized to nonspecific uptake in occipital cortex and indices of asymmetry for each whole striatum as well as for putamen and caudate separately were calculated. SPECT studies did not reveal asymmetry of DaTSCAN and IBZM binding in striatum in all studied subjects. The current clinical diagnostic criteria of HT are presumably insufficiently specific and when using them we identify patients both with and without the involvement of dopaminergic system. These two groups may represent tremor disorders of similar phenomenology but of different pathomechanism.
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