ArticleHuman genetics2017
A multi-stage genome-wide association study of uterine fibroids in African Americans.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Human genetics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers, 5 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 5 pooled it
3.4field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 5 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Multi-omics Approaches for Biomarker Discovery of Uterine Fibroids: A Systematic Review.Advances in therapy · 2026Pooled it
- Genome-wide meta-analysis identifies novel risk loci for uterine fibroids within and across multiple ancestry groups.Nature communications · 2025Pooled it
- Integrating leiomyoma genetics, epigenomics, and single-cell transcriptomics reveals causal genetic variants, genes, and cell types.Nature communications · 2024Pooled it
- Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.Nature communications · 2019Pooled it
- Variants associating with uterine leiomyoma highlight genetic background shared by various cancers and hormone-related traits.Nature communications · 2018Pooled it
- UTERINE FIBROIDS.Physiological reviews · 2025Review
- Obesity/Overweight as a Meaningful Modifier of Associations Between Gene Polymorphisms Affecting the Sex Hormone-Binding Globulin Content and Uterine Myoma.Life (Basel, Switzerland) · 2025Article
- The Uterus Keeps the Score: Black Women Academics' Insights and Coping with Uterine Fibroids.Journal of health and social behavior · 2025Article
- Constructing a multi-ancestry polygenic risk score for uterine fibroids using publicly available data highlights need for inclusive genetic research.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2025Article
- Uterine fibroids show evidence of shared genetic architecture with blood pressure traits.Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing · 2025Article
- Review
- Racial disparity in uterine leiomyoma: new insights of genetic and environmental burden in myometrial cells.Molecular human reproduction · 2024Review
- Novel Approaches to Possible Targeted Therapies and Prophylaxis of Uterine Fibroids.Diseases (Basel, Switzerland) · 2023Review
- Uterine leiomyomata and keloids fibrosis origins: a mini-review of fibroproliferative diseases.American journal of physiology. Cell physiology · 2023Review
- Challenges and Opportunities for Data Science in Women's Health.Annual review of biomedical data science · 2023Review
- A View on Uterine Leiomyoma Genesis through the Prism of Genetic, Epigenetic and Cellular Heterogeneity.International journal of molecular sciences · 2023Review
- Cytohesin-4 Upregulation in Glioma-Associated M2 Macrophages Is Correlated with Pyroptosis and Poor Prognosis.Journal of molecular neuroscience : MN · 2023Article
- Evidence of a causal effect of genetic tendency to gain muscle mass on uterine leiomyomata.Nature communications · 2023Article
- A Common Genetic Factor Underlies Genetic Risk for Gynaecological and Reproductive Disorders and Is Correlated with Risk to Depression.Neuroendocrinology · 2023Article
- Genetic Contribution of the Adrenergic, Cholinergic, and Serotonergic Systems to Leiomyoma Development and Treatment.International journal of molecular and cellular medicine · 2023Article
Corrections and comments
- Erratum issued
Authors and funding
27 authors at 10 institutions in 2 countries.
Jacklyn N HellwegeDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Janina M JeffCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lauren A WiseDepartment of Epidemiology, Boston University School of Public Health, Boston, MA, USA.
C Scott GallagherDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Melissa WellonsDivision of Diabetes, Endocrinology and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Katherine E HartmannInstitute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA.
Sarah F JonesDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Eric S TorstensonDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Scott DickinsonSection of Genetic Medicine, The University of Chicago, Chicago, IL, USA.
Edward A Ruiz-NarváezSlone Epidemiology Center at Boston University, Boston, MA, USA.
Nadin RohlandDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Alexander AllenDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
David ReichDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Arti TandonDepartment of Genetics, Harvard Medical School, Boston, MA, USA.
Bogdan PasaniucDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Nicholas MancusoDepartment of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Hae Kyung ImSection of Genetic Medicine, The University of Chicago, Chicago, IL, USA.
David A Hinds23andMe, Inc., Mountain View, CA, USA.
Julie R PalmerSlone Epidemiology Center at Boston University, Boston, MA, USA.
Lynn RosenbergSlone Epidemiology Center at Boston University, Boston, MA, USA.
Joshua C DennyDepartment of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN, USA.
Dan M RodenVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA.
Elizabeth A StewartDepartments of Obstetrics and Gynecology and Surgery, Mayo Clinic and Mayo Clinic School of Medicine, Rochester, MN, USA.
Cynthia C MortonBroad Institute of Harvard and MIT, Cambridge, MA, USA.
Eimear E KennyCharles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Todd L EdwardsDivision of Epidemiology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Digna R Velez EdwardsVanderbilt Genetics Institute, Vanderbilt University Medical Center, Nashville, TN, USA. digna.r.velez.edwards@vanderbilt.edu.
Vanderbilt University Medical Center · USHarvard University · USBoston University · USIcahn School of Medicine at Mount Sinai · USUniversity of California, Los Angeles · USUniversity of Chicago · US23andMe (United States) · USBroad Institute · USMayo Clinic in Arizona · USVanderbilt University · US
Funding
The Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MA Follow-up Study for Causes of Cancer in Black WomenU01CA164974 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Kimberly A. Bertrand, Yvette C Cozier · 2017 to 2026
$24.0MFOLLOW-UP STUDY FOR CAUSES OF ILLNESS IN BLACK WOMENR01CA058420 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 1999 to 2013
$20.7MA Follow-up Study for Causes of Cancer in Black WomenUM1CA164974 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROSENBERG, LYNN · 2012 to 2017
$13.7MVanderbilt/Meharry Initiative for Minority Student DvptR25GM062459 · NIGMS · VANDERBILT UNIVERSITY · PI VELEZ EDWARDS, DIGNA R · 2002 to 2020
$10.4MGene Polymorphisms in Relation to Cancer in Black WomenR01CA098663 · NCI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI PALMER, JULIE R · 2003 to 2012
$5.3MVGER, the Vanderbilt Genome-Electronic Records ProjectU01HG008672 · NHGRI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DENNY, JOSHUA C., RODEN, DAN M · 2015 to 2019
$5.1MBiorepository for Genomic Medicine in diverse CommunitiesU01HG006380 · NHGRI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BOTTINGER, ERWIN P. · 2011 to 2015
$4.5MLarge-scale studies in eMERGE to discover the genetic determinants of uterine fibroidsR01HD093671 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI EDWARDS, TODD L, VELEZ EDWARDS, DIGNA R · 2017 to 2021
$3.3MUnderstanding the genetic risk underlying racial disparities in uterine fibroids - Diversity SupplementR01HD074711 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI VELEZ EDWARDS, DIGNA R · 2013 to 2017
$2.9MVanderbilt Training Program in Molecular and Genetic Epidemiology of CancerR25CA160056 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HEIMBURGER, DOUGLAS CORBETT, SHU, XIAO-OU · 2012 to 2016
$2.1MGenetic Admixture Study of Uterine Fibroids in African American WomenR01HD057966 · NICHD · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WISE, LAUREN A · 2009 to 2012
$2.0MNCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1TR000445NCI NIH HHS R01 CA058420NCI NIH HHS R01 CA098663NCI NIH HHS R01CA098663NCI NIH HHS R01CA58420NCI NIH HHS R25 CA160056NCI NIH HHS R25CA160056NCI NIH HHS U01 CA164974NCI NIH HHS UM1 CA164974NCI NIH HHS UM1CA164974NCRR NIH HHS S10 RR025141NHGRI NIH HHS U01 HG006380NHGRI NIH HHS U01HG006380NHGRI NIH HHS U01 HG008672NHGRI NIH HHS U01HG08672-01NHLBI NIH HHS and HHSN268200900041CNHLBI NIH HHS HHSN268200900041CNHLBI NIH HHS HHSN268201300025CNHLBI NIH HHS HHSN268201300026CNHLBI NIH HHS HHSN268201300027CNHLBI NIH HHS HHSN268201300028CNHLBI NIH HHS HHSN268201300029CNHLBI NIH HHS N01 HC065226NHLBI NIH HHS N01-HC-65226NICHD NIH HHS R01 HD057966NICHD NIH HHS R01 HD060530NICHD NIH HHS R01 HD074711NICHD NIH HHS R01 HD093671NICHD NIH HHS R03 HD078567NIGMS NIH HHS R25 GM062459NIH HHS S10 OD018522NIH HHS S10 OD023680
Abstract
Uterine fibroids are benign tumors of the uterus affecting up to 77% of women by menopause. They are the leading indication for hysterectomy, and account for $34 billion annually in the United States. Race/ethnicity and age are the strongest known risk factors. African American (AA) women have higher prevalence, earlier onset, and larger and more numerous fibroids than European American women. We conducted a multi-stage genome-wide association study (GWAS) of fibroid risk among AA women followed by in silico genetically predicted gene expression profiling of top hits. In Stage 1, cases and controls were confirmed by pelvic imaging, genotyped and imputed to 1000 Genomes. Stage 2 used self-reported fibroid and GWAS data from 23andMe, Inc. and the Black Women's Health Study. Associations with fibroid risk were modeled using logistic regression adjusted for principal components, followed by meta-analysis of results. We observed a significant association among 3399 AA cases and 4764 AA controls at rs739187 (risk-allele frequency = 0.27) in CYTH4 (OR (95% confidence interval) = 1.23 (1.16-1.30), p value = 7.82 × 10
Indexed as
Cell Adhesion MoleculesGene Expression Regulation, NeoplasticGene FrequencyGuanine Nucleotide Exchange FactorsLeiomyomaNeoplasm ProteinsUterine NeoplasmsAdultAllelesBlack or African AmericanFemaleGenetic LociGenome-Wide Association StudyHumansMiddle AgedRisk FactorsCell Adhesion MoleculesCYTH4 protein, humanGuanine Nucleotide Exchange FactorsNeoplasm Proteins
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.