Evidence map›Paper›PMID 28836047›Full record

ArticleMolecular and cellular biochemistry2018

Adaptive regulation of riboflavin transport in heart: effect of dietary riboflavin deficiency in cardiovascular pathogenesis.

Tamilarasan Udhayabanu, Sellamuthu Karthi, Ayyavu Mahesh, Perumal Varalakshmi, Andreea Manole, Henry Houlden, Balasubramaniem Ashokkumar

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Tamilarasan UdhayabanuDepartment of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, 625021, India.
Sellamuthu KarthiDepartment of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, 625021, India.
Ayyavu MaheshCentre for Excellence in Genomics Science, School of Biological Sciences, Madurai Kamaraj University, Madurai, 625021, India.
Perumal VaralakshmiDepartment of Molecular Microbiology, School of Biotechnology, Madurai Kamaraj University, Madurai, 625021, India.
Andreea ManoleDepartment of Molecular Neuroscience and Neurogenetics Laboratory, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Henry HouldenDepartment of Molecular Neuroscience and Neurogenetics Laboratory, UCL Institute of Neurology, Queen Square, London, WC1N 3BG, UK.
Balasubramaniem AshokkumarDepartment of Genetic Engineering, School of Biotechnology, Madurai Kamaraj University, Madurai, 625021, India. rbashokkumar@yahoo.com.ORCID http://orcid.org/0000-0003-2213-5400
Madurai Kamaraj University · INNational Hospital for Neurology and Neurosurgery · GB

Funding

DBT-RGYI BT/PR15134/GBD/27/330/2011ICMR INDO/FRC/452/(Y83)/2016-17-IHD
6 · The paper itself

Abstract

Deficiency or defective transport of riboflavin (RF) is known to cause neurological disorders, cataract, cardiovascular anomalies, and various cancers by altering the biochemical pathways. Mechanisms and regulation of RF uptake process is well characterized in the cells of intestine, liver, kidney, and brain origin, while very little is known in the heart. Hence, we aimed to understand the expression and regulation of RF transporters (rRFVT-1 and rRFVT-2) in cardiomyocytes during RF deficiency and also investigated the role of RF in ischemic cardiomyopathy and mitochondrial dysfunction in vivo. Riboflavin uptake assay revealed that RF transport in H9C2 is (1) significantly higher at pH 7.5, (2) independent of Na

Indexed as

AnimalsBiological Transport, ActiveCell LineMaleMembrane Transport ProteinsMyocardiumMyocytes, CardiacRatsRats, WistarRiboflavinRiboflavin DeficiencyMembrane Transport ProteinsRiboflavinSlc52a2 protein, ratCardiovascular diseasesHomocysteineMitochondrial dysfunctionRiboflavin

Identifiers

PMID28836047
OpenAlexW2748883259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.