ArticleInternational orthopaedics2017
Prevalence and clinical outcomes of hip fractures and subchondral insufficiency fractures of the femoral head in patients with tumour-induced osteomalacia.
Article in International orthopaedics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 23 citations in OpenAlex.
- Surgical Treatment of Tumor-Induced Osteomalacia With Causative Tumors Affecting the Long Bones.Orthopaedic surgery · 2026Article
- Surgical Treatment for Osteomalacia Induced by Causative Tumor in the Knee Joint Region: A Single-Center Retrospective Clinical Study Over 10 Years.Orthopaedic surgery · 2025Article
- Surgical treatment as a key determinant of outcome in phosphaturic mesenchymal tumors of the bone and soft tissue: a systematic review and case series.EFORT open reviews · 2025Article
- Orthopedic surgical treatment of osteomalacia induced by culprit soft tissue tumor in the hip region: a single-center retrospective study.BMC musculoskeletal disorders · 2025Article
- Case Report: Phosphaturic mesenchymal tumor presenting solely as knee pain without hypophosphatemia.Frontiers in oncology · 2025Article
- Preoperative evaluation and orthopedic surgical strategies for tumor-induced osteomalacia.Journal of bone oncology · 2024Review
- [Clinical features, diagnostics and treatment of FGF23 secreting tumors: series of 40 clinical cases].Problemy endokrinologii · 2023Article
- Subchondral insufficiency fractures, subchondral insufficiency fractures with osteonecrosis, and other apparently spontaneous subchondral bone lesions of the knee-pathogenesis and diagnosis at imaging.Insights into imaging · 2023Review
- Risk factors for subchondral insufficiency fracture of the femoral head in renal transplant patients.Journal of bone and mineral metabolism · 2022Article
- Phosphaturic Mesenchymal Tumor-induced Osteomalacia Masquerading as an Orthopedic Polytrauma Patient: A Case Report and Review of the Literature.Journal of orthopaedic case reports · 2022Article
- Surgical treatment of recurrent spinal phosphaturic mesenchymal tumor-induced osteomalacia: A case report.Medicine · 2020Article
- Subchondral insufficiency fractures of the femoral head: systematic review of diagnosis, treatment and outcomes.Journal of hip preservation surgery · 2020Article
- Successful treatment of tumor-induced osteomalacia causing by phosphaturic mesenchymal tumor of the foot.Medicine · 2019Article
- Inversion of the acetabular labrum causes increased localized contact pressure on the femoral head: a biomechanical study.International orthopaedics · 2019Article
- Citations, non-citations and visibility of International Orthopaedics in 2017.International orthopaedics · 2018Article
- Phosphaturic mesenchymal tumors: what an endocrinologist should know.Journal of endocrinological investigation · 2018Review
- Prudence for Deformity Correction in Surgically Treated Tumour-Induced Osteomalacia Patients.Indian journal of endocrinology and metabolismArticle
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTumour-induced osteomalacia (TIO) is a rare paraneoplastic syndrome usually caused by phosphaturic mesenchymal tumours, leading to great distress due to bone pain and affecting quality of life (QoL). This study aimed to investigate the prevalence and clinical outcomes of hip fractures and subchondral insufficiency fractures (SIF) of the femoral head.
methodsTwelve TIO patients were treated between January 2000 and December 2016 at our hospital. All underwent surgery for the tumour causing TIO, and complete removal of the tumour was accomplished in nine of 12 cases. Plain radiographs of the hip were obtained in all cases, and magnetic resonance imaging (MRI) was obtained from 15 hips representing eight patients before tumour removal. We evaluated the prevalence of hip fractures or SIF and their clinical outcomes.
resultsHip fractures were observed in six of 12 cases, and the total number of fractures was nine, of which five were femoral neck, two were intertrochanteric and two were subtrochanteric fractures. Conservative treatment, regardless of complete remission of TIO, was successful except in one case with impending subtrochanteric fracture. SIFs were observed in 11 of 24 hips. Seven of 11 hips with SIF showed progression after surgery for tumour resection.
conclusionsHip fractures and SIF are highly prevalent in TIO patients. Surgical and medical treatment for TIO is sufficient for treating hip fractures conservatively. However, SIF tends to show progression of femoral head collapse, serving as the main cause of pain after successful TIO treatment.
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