ArticleScience advances2017
Impaired DNA replication derepresses chromatin and generates a transgenerationally inherited epigenetic memory.
Article in Science advances, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- Transgenerational somatic mutations and epigenetic imprints on selected DNA repair gene promoters in Arabidopsis thaliana due to pesticides.Plant biology (Stuttgart, Germany) · 2026Article
- Developmental stage dominates cell-type identity and reveals a chromatin regulatory function for Rad50 in Drosophila.Nucleic acids research · 2026Article
- A unified framework governing the establishment and maintenance of transgenerational epigenetic inheritance.Genetics · 2025Article
- Regulation of MAP Kinase signaling by the insulin-like growth factor pathway duringmicroPublication biology · 2025Article
- Multigenerational, Indirect Exposure to Pyrethroids Demonstrates Potential Compensatory Response and Reduced Toxicity at Higher Salinity in Estuarine Fish.Environmental science & technology · 2024Article
- Gametes deficient for Pot1 telomere binding proteins alter levels of telomeric foci for multiple generations.Communications biology · 2021Article
- Intergenerational and transgenerational epigenetic inheritance in animals.Nature cell biology · 2019Review
- A DNA repair protein and histone methyltransferase interact to promote genome stability in the Caenorhabditis elegans germ line.PLoS genetics · 2019Article
- Accurate Recycling of Parental Histones Reproduces the Histone Modification Landscape during DNA Replication.Molecular cell · 2018Article
- Shaping epigenetic memory via genomic bookmarking.Nucleic acids research · 2018Article
- Recent advances in understanding DNA replication: cell type-specific adaptation of the DNA replication program.F1000Research · 2018Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Impaired DNA replication is a hallmark of cancer and a cause of genomic instability. We report that, in addition to causing genetic change, impaired DNA replication during embryonic development can have major epigenetic consequences for a genome. In a genome-wide screen, we identified impaired DNA replication as a cause of increased expression from a repressed transgene in
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.