ArticleScientific reports2017
In vivo photothermal optical coherence tomography of endogenous and exogenous contrast agents in the eye.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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Who cites it
38 citing papers in PubMed, 62 citations in OpenAlex.
- Phase-sensitive photothermal optical coherence tomography: decoupling optical and thermal tissue properties.Biomedical optics express · 2026Article
- Computational and experimental investigation of nanoparticle effects on tissue optical properties and optical coherence tomography imaging.Biomedical optics express · 2026Article
- Imaging techniques for the detection of choroidal neovascularization.Experimental eye research · 2025Review
- OCT in Oncology and Precision Medicine: From Nanoparticles to Advanced Technologies and AI.Bioengineering (Basel, Switzerland) · 2025Review
- Imaging melanin-associated organelles in the retinal pigment epithelium via visible light OCT redshift.Optics letters · 2025Article
- Gold Nanoparticles for Retinal Molecular Optical Imaging.International journal of molecular sciences · 2024Review
- Artificial neural network for enhancing signal-to-noise ratio and contrast in photothermal optical coherence tomography.Scientific reports · 2024Article
- Advanced nanomaterials for imaging of eye diseases.ADMET & DMPK · 2024Review
- Photothermal optical coherence tomography for 3D live cell detection and mapping.Optics continuum · 2023Article
- Review
- Next-generation nanomaterials: advancing ocular anti-inflammatory drug therapy.Journal of nanobiotechnology · 2023Review
- Chemically revised conducting polymers with inflammation resistance for intimate bioelectronic electrocoupling.Bioactive materials · 2023Review
- Label-free photothermal optical coherence microscopy to locate desired regions of interest in multiphoton imaging of volumetric specimens.Scientific reports · 2023Article
- Recent achievements in nano-based technologies for ocular disease diagnosis and treatment, review and update.Journal of nanobiotechnology · 2022Review
- Computational refocusing of Jones matrix polarization-sensitive optical coherence tomography and investigation of defocus-induced polarization artifacts.Biomedical optics express · 2022Article
- Molecular Contrast Optical Coherence Tomography and Its Applications in Medicine.International journal of molecular sciences · 2022Review
- Bismuth Selenide Nanostructured Clusters as Optical Coherence Tomography Contrast Agents: Beyond Gold-Based Particles.ACS photonics · 2022Article
- The Development and Clinical Application of Innovative Optical Ophthalmic Imaging Techniques.Frontiers in medicine · 2022Review
- Spectral- and Polarization-Dependent Scattering of Gold Nanobipyramids for Exogenous Contrast in Optical Coherence Tomography.Nano letters · 2021Article
- Gold Nanorod Enhanced Photoacoustic Microscopy and Optical Coherence Tomography of Choroidal Neovascularization.ACS applied materials & interfaces · 2021Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Optical coherence tomography (OCT) has become a standard-of-care in retinal imaging. OCT allows non-invasive imaging of the tissue structure but lacks specificity to contrast agents that could be used for in vivo molecular imaging. Photothermal OCT (PT-OCT) is a functional OCT-based technique that has been developed to detect absorbers in a sample. We demonstrate in vivo PT-OCT in the eye for the first time on both endogenous (melanin) and exogenous (gold nanorods) absorbers. Pigmented mice and albino mice (n = 6 eyes) were used to isolate the photothermal signal from the melanin in the retina. Pigmented mice with laser-induced choroidal neovascularization lesions (n = 7 eyes) were also imaged after a systemic injection of gold nanorods to observe their passive accumulation in the retina. This experiment demonstrates the feasibility of PT-OCT to image the distribution of both endogenous and exogenous absorbers in the mouse retina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.