ArticleScientific reports2017
The vaginal microbiome of pregnant women is less rich and diverse, with lower prevalence of Mollicutes, compared to non-pregnant women.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
108 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Vaginal metatranscriptome meta-analysis reveals functional BV subgroups and novel colonisation strategies.Microbiome · 2024Pooled it
- Gestational diabetes as a risk factor for GBS maternal rectovaginal colonization: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2024Pooled it
- The Association Between Vaginal Microbiota Dysbiosis, Bacterial Vaginosis, and Aerobic Vaginitis, and Adverse Pregnancy Outcomes of Women Living in Sub-Saharan Africa: A Systematic Review.Frontiers in public health · 2020Pooled it
- The Effect of Probiotics on Health in Pregnancy and Infants: A Randomized, Double-Blind, Placebo-Controlled Trial.Nutrients · 2025Trial
- A randomized controlled trial of the effects of whole grains versus refined grains diets on the microbiome in pregnancy.Scientific reports · 2022Trial
- The cervicovaginal gut microbiota axis as a key determinant of systemic physiology.Gut microbes · 2026Review
- Alterations in Vaginal Microbiota Associated with Pregnancy Outcomes in Dairy Cows Revealed by 16S rRNA Gene Sequencing.Microorganisms · 2026Article
- Vaginal microbiome composition in pregnant and non-pregnant women: community structure, population variation, clinical impact, and metagenomics approaches.Infection and immunity · 2026Review
- Lactobacillus iners at the nexus of microbiota, immunity, and pregnancy.Journal of reproductive immunology · 2026Review
- The Pathophysiology of Spontaneous Preterm Birth: Emerging Mechanisms Reviewed by the Preterm Birth International Collaborative.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- The vaginal microbiome in pregnancy and preterm birth: mechanisms, disparities, and therapeutic opportunities.NPJ biofilms and microbiomes · 2026Review
- Retrospective comparative analysis of pre-IVF vaginal and semen microbiological cultures in infertile couples highlights absence of microbial concordance.Frontiers in cellular and infection microbiology · 2026Article
- VaginalFrontiers in cellular and infection microbiology · 2026Article
- Probiotic ice cream influences gut and vaginal microbiota in women at high risk of preterm birth: a randomized controlled study.Maternal health, neonatology and perinatology · 2025Article
- Oral, Vaginal, and Placental Microbiota Profiles in Japanese Pregnancies with Preterm Birth and Chronic Abruption-Oligohydramnios Sequence (CAOS): A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2025Article
- Vaginal microbiome and recurrent pregnancy loss.Infection and immunity · 2025Review
- Correlation between Lactobacillus of Vaginal Microbiota and the Pregnancy Outcomes for Patients Experiencing Recurrent Miscarriage.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Review
- The sow vaginal and gut microbiota associated with longevity and reproductive performance.Journal of animal science and biotechnology · 2025Article
- Vaginal Microbiome and the Risk of Preterm Birth in Women Living With HIV: A Scoping Review.American journal of reproductive immunology (New York, N.Y. : 1989) · 2024Article
48 more citing papers are in PubMed but not listed here.
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8 authors.
Funding
Abstract
The vaginal microbiome plays an important role in maternal and neonatal health. Imbalances in this microbiota (dysbiosis) during pregnancy are associated with negative reproductive outcomes, such as pregnancy loss and preterm birth, but the underlying mechanisms remain poorly understood. Consequently a comprehensive understanding of the baseline microbiome in healthy pregnancy is needed. We characterized the vaginal microbiomes of healthy pregnant women at 11-16 weeks of gestational age (n = 182) and compared them to those of non-pregnant women (n = 310). Profiles were created by pyrosequencing of the cpn60 universal target region. Microbiome profiles of pregnant women clustered into six Community State Types: I, II, III, IVC, IVD and V. Overall microbiome profiles could not be distinguished based on pregnancy status. However, the vaginal microbiomes of women with healthy ongoing pregnancies had lower richness and diversity, lower prevalence of Mycoplasma and Ureaplasma and higher bacterial load when compared to non-pregnant women. Lactobacillus abundance was also greater in the microbiomes of pregnant women with Lactobacillus-dominated CSTs in comparison with non-pregnant women. This study provides further information regarding characteristics of the vaginal microbiome of low-risk pregnant women, providing a baseline for forthcoming studies investigating the diagnostic potential of the microbiome for prediction of adverse pregnancy outcomes.
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