ArticleScientific reports2017
A prospective multicenter study on genome wide associations to ranibizumab treatment outcome for age-related macular degeneration.
Open access · goldAbstract readMulticenter Study
In one paragraph
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
What it found
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The trial behind it
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- Genetic factors associated with response to as-needed aflibercept therapy for typical neovascular age-related macular degeneration and polypoidal choroidal vasculopathy.Scientific reports · 2020Trial
- Genetic factors associated with response to as-needed brolucizumab treatment for exudative age-related macular degeneration.Japanese journal of ophthalmology · 2026Article
- Exudative Age-Related Macular Degeneration: Association between Treatment Efficacy and Single-Nucleotide Variants inInternational journal of molecular sciences · 2024Article
- Article
- Neovascular age-related macular degeneration: disease pathogenesis and current state of molecular biomarkers predicting treatment response-a scoping review.BMJ open ophthalmology · 2024Article
- Genetic Association Analysis of Anti-VEGF Treatment Response in Neovascular Age-Related Macular Degeneration.International journal of molecular sciences · 2022Observational
- Biomarkers as Predictive Factors of Anti-VEGF Response.Biomedicines · 2022Review
- Outcomes of a 2-year treat-and-extend regimen with aflibercept for diabetic macular edema.Scientific reports · 2021Article
- Hypothetical pathogenesis of age-related macular degeneration and pachychoroid diseases derived from their genetic characteristics.Japanese journal of ophthalmology · 2020Review
- Association between Polygenic Risk Score and One-Year Outcomes Following As-Needed Aflibercept Therapy for Exudative Age-Related Macular Degeneration.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Title: Pachydrusen in Fellow Eyes Predict Response to Aflibercept Monotherapy in Patients with Polypoidal Choroidal Vasculopathy.Journal of clinical medicine · 2020Article
- Characteristics of Pachychoroid Diseases and Age-Related Macular Degeneration: Multimodal Imaging and Genetic Backgrounds.Journal of clinical medicine · 2020Review
- Article
- Impact of methylenetetrahydrofolate reductase C677T polymorphism on the efficacy of photodynamic therapy in patients with neovascular age-related macular degeneration.Scientific reports · 2019Article
- Analysis of genetic polymorphisms for age-related macular degeneration (AMD) in Chinese Tujia ethnic minority group.BMC medical genetics · 2019Article
- Genetic biomarkers in the VEGF pathway predicting response to anti-VEGF therapy in age-related macular degeneration.BMJ open ophthalmology · 2019Article
- Genome-wide association study suggests four variants influencing outcomes with ranibizumab therapy in exudative age-related macular degeneration.Journal of human genetics · 2018Article
- Exploring the Use of Molecular Biomarkers for Precision Medicine in Age-Related Macular Degeneration.Molecular diagnosis & therapy · 2018Review
- HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model.EBioMedicine · 2018Article
Corrections and comments
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Authors and funding
58 authors at 20 institutions in 2 countries.
Kenji YamashiroDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan. yamashro@kuhp.kyoto-u.ac.jp.ORCID 0000-0001-9354-8558
Keisuke MoriDepartment of Ophthalmology, Saitama Medical University, Iruma, Saitama, 350-0495, Japan.ORCID 0000-0001-6671-7192
Shigeru HondaDepartment of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo, Kobe, 650-0017, Japan.
Mariko KanoDepartment of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, 960-1247, Japan.
Yasuo YanagiDepartment of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.
Akira ObanaDepartment of Ophthalmology, Seirei Hamamatsu General Hospital, Shizuoka, 430-8558, Japan.
Yoichi SakuradaDepartment of Ophthalmology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan.
Taku SatoDepartment of Ophthalmology, Gunma University School of Medicine, Gunma, 371-0034, Japan.
Yoshimi NagaiDepartment of Ophthalmology, Kansai Medical University, Osaka, 573-1191, Japan.
Taiichi HikichiOhtsuka Eye Hospital, Sapporo, 001-0016, Japan.
Yasushi KataokaMiyata Ophthalmic Hospital, Miyazaki, 885-0051, Japan.
Chikako HaraDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, 565-0871, Japan.
Yasurou KoyamaDepartment of Ophthalmology, Shimane University Faculty of Medicine, Shimane, 693-0021, Japan.
Hideki KoizumiDepartment of Ophthalmology, Tokyo Women's Medical University, School of Medicine, Tokyo, 162-8666, Japan.
Munemitsu YoshikawaDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan.
Masahiro MiyakeDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan.
Isao NakataDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan.
Takashi TsuchihashiDepartment of Ophthalmology, Saitama Medical University, Iruma, Saitama, 350-0495, Japan.
Kuniko Horie-InoueDivision of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama, 350-1241, Japan.
Wataru MatsumiyaDepartment of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo, Kobe, 650-0017, Japan.
Masashi OgasawaraDepartment of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, 960-1247, Japan.
Ryo ObataDepartment of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.
Seigo YoneyamaDepartment of Ophthalmology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan.
Hidetaka MatsumotoDepartment of Ophthalmology, Gunma University School of Medicine, Gunma, 371-0034, Japan.
Masayuki OhnakaDepartment of Ophthalmology, Kansai Medical University, Osaka, 573-1191, Japan.
Hirokuni KitameiOhtsuka Eye Hospital, Sapporo, 001-0016, Japan.
Kaori SayanagiHikichi Eye Clinic, Sapporo, 060-0807, Japan.
Sotaro OotoDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan.
Hiroshi TamuraDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan.ORCID 0000-0002-7740-2732
Akio OishiDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan.
Sho KabasawaDepartment of Ophthalmology, Saitama Medical University, Iruma, Saitama, 350-0495, Japan.
Kazuhiro UeyamaDepartment of Ophthalmology, Saitama Medical University, Iruma, Saitama, 350-0495, Japan.
Akiko MikiDepartment of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo, Kobe, 650-0017, Japan.
Naoshi KondoDepartment of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo, Kobe, 650-0017, Japan.
Hiroaki BesshoDepartment of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo, Kobe, 650-0017, Japan.
Masaaki SaitoDepartment of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, 960-1247, Japan.
Hidenori TakahashiDepartment of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.ORCID 0000-0001-5331-4730
Xue TanDepartment of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.
Keiko AzumaDepartment of Ophthalmology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, 113-0033, Japan.
Wataru KikushimaDepartment of Ophthalmology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan.
Ryo MukaiDepartment of Ophthalmology, Gunma University School of Medicine, Gunma, 371-0034, Japan.
Akihiro OhiraDepartment of Ophthalmology, Shimane University Faculty of Medicine, Shimane, 693-0021, Japan.
Fumi GomiDepartment of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, 565-0871, Japan.
Kazunori MiyataMiyata Ophthalmic Hospital, Miyazaki, 885-0051, Japan.
Kanji TakahashiDepartment of Ophthalmology, Kansai Medical University, Osaka, 573-1191, Japan.
Shoji KishiDepartment of Ophthalmology, Gunma University School of Medicine, Gunma, 371-0034, Japan.
Hiroyuki IijimaDepartment of Ophthalmology, Faculty of Medicine, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan.
Tetsuju SekiryuDepartment of Ophthalmology, Fukushima Medical University School of Medicine, Fukushima, 960-1247, Japan.
Tomohiro IidaDepartment of Ophthalmology, Tokyo Women's Medical University, School of Medicine, Tokyo, 162-8666, Japan.
Takuya AwataDepartment of Diabetes, Endocrinology and Metabolism, International University of Health and Welfare Hospital, 537-3 Iguchi, Nasu-Shiobara, Tochigi, 329-2763, Japan.
Satoshi InoueDivision of Gene Regulation and Signal Transduction, Research Center for Genomic Medicine, Saitama Medical University, Hidaka, Saitama, 350-1241, Japan.
Ryo YamadaCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
Fumihiko MatsudaCenter for Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, 606-8507, Japan.
Akitaka TsujikawaDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan.
Akira NegiDepartment of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo, Kobe, 650-0017, Japan.
Shin YoneyaDepartment of Ophthalmology, Saitama Medical University, Iruma, Saitama, 350-0495, Japan.
Takeshi IwataDivision of Molecular and Cellular Biology, National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, 152-8902, Japan.ORCID 0000-0003-1447-0081
Nagahisa YoshimuraDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Sakyo, Kyoto, 606-8507, Japan.
Kyoto University · JPKobe University · JPSaitama Medical University · JPFukushima Medical University · JPGunma University · JPUniversity of Yamanashi · JPKansai Medical University · JPOhtsuka Eye Hospital · JPThe University of Tokyo · JPInternational University of Health and Welfare · JPMiyata Eye Hospital · JPShimane University · JPTokyo Women's Medical University · JPHyogo Medical University · JPJichi Medical University · JPKagawa University · JPNational University of Singapore · SGSeirei Hamamatsu General Hospital · JPThe University of Osaka · JPTokyo Medical Center · JP
Funding
No grant is acknowledged in the PubMed record.
Abstract
We conducted a genome-wide association study (GWAS) on the outcome of anti-VEGF treatment for exudative age-related macular degeneration (AMD) in a prospective cohort. Four hundred and sixty-one treatment-naïve AMD patients were recruited at 13 clinical centers and all patients were treated with 3 monthly injections of ranibizumab followed by pro re nata regimen treatment for one year. Genomic DNA was collected from all patients for a 2-stage GWAS on achieving dry macula after the initial treatment, the requirement for an additional treatment, and visual acuity changes during the 12-month observation period. In addition, we evaluated 9 single-nucleotide polymorphisms (SNPs) in 8 previously reported AMD-related genes for their associations with treatment outcome. The discovery stage with 256 patients evaluated 8,480,849 SNPs, but no SNPs showed genome-wide level significance in association with treatment outcomes. Although SNPs with P-values of <5 × 10
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyAgedAged, 80 and overAllelesAngiogenesis InhibitorsFemaleGenetic MarkersHumansMacular DegenerationMaleMiddle AgedOdds RatioPolymorphism, Single NucleotideRanibizumabSeverity of Illness IndexAngiogenesis InhibitorsGenetic MarkersRanibizumab
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