Evidence map›Paper›PMID 28835448›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2017

Cyclical blood flow restriction resistance exercise: a potential parallel to remote ischemic preconditioning?

Justin D Sprick, Caroline A Rickards

Abstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Trial
  2. A peripheral perspective on brain health: vascular and skeletal muscle contributions.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Combining remote ischemic preconditioning and aerobic exercise: a novel adaptation of blood flow restriction exercise.American journal of physiology. Regulatory, integrative and comparative physiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Justin D SprickInstitute for Cardiovascular and Metabolic Diseases, University of North Texas Health Science Center, Fort Worth, Texas.
Caroline A RickardsInstitute for Cardiovascular and Metabolic Diseases, University of North Texas Health Science Center, Fort Worth, Texas caroline.rickards@unthsc.edu.

Funding

Training in the Neurobiology of Aging and Alzheimer's DiseaseT32AG020494 · NIA · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI ROBERT Clinton BARBER, NATHALIE SUMIEN · 2002 to 2026
$6.9M
Potential Therapeutic Benefits of Remote Ischemic Preconditioning vs. Occlusive Exercise-an acute studyF31HL134242 · NHLBI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI SPRICK, JUSTIN DANIEL · 2017 to 2017
$28k
NHLBI NIH HHS F31 HL134242NIA NIH HHS T32 AG020494
6 · The paper itself

Abstract

Remote ischemic preconditioning (RIPC) is characterized by the cyclical application of limb blood flow restriction and reperfusion and has been shown to protect vital organs during a subsequent ischemic insult. Blood flow restriction exercise (BFRE) similarly combines bouts of blood flow restriction with low-intensity exercise and thus could potentially emulate the protection demonstrated by RIPC. One concern with BFRE, however, is the potential for an augmented rise in sympathetic outflow due to greater activation of the exercise pressor reflex. Because of the use of lower workloads, however, we hypothesized that BFRE would elicit an attenuated increase in sympathetic outflow [assessed via plasma norepinephrine (NE) and mean arterial pressure (MAP)] and middle cerebral artery velocity (MCAv) when compared with conventional exercise (CE). Fifteen subjects underwent two leg press exercise interventions:

Indexed as

AdultBlood Flow VelocityExerciseFemaleHemodynamicsHumansIschemic PreconditioningMaleMiddle Cerebral ArteryMuscle, SkeletalReflexRegional Blood FlowResistance Trainingexercise for cardiac rehabilitationexercise for stroke rehabilitationKAATSUvascular occlusion training

Identifiers

PMID28835448
PMCPMC5792150

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.