Evidence map›Paper›PMID 28835377›Full record

ArticleMolecular biology of the cell2017

Distinct effects of tubulin isotype mutations on neurite growth in

Chaogu Zheng, Margarete Diaz-Cuadros, Ken C Q Nguyen, David H Hall, Martin Chalfie

Erratum issuedAbstract read
In one paragraph

Article in Molecular biology of the cell, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. TUBB3 and KIF21A in neurodevelopment and disease.Frontiers in neuroscience · 2023
    Review
  12. Article
  13. Article
  14. H-ABC- and dystonia-causingScience advances · 2022
    Article
  15. The Expression and Function of Tubulin Isotypes inFrontiers in cell and developmental biology · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. TBA-7 is not a microtubule-destabilizing tubulin.Molecular biology of the cell · 2021
    Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Chaogu ZhengDepartment of Biological Sciences, Columbia University, New York, NY 10027.
Margarete Diaz-CuadrosDepartment of Biological Sciences, Columbia University, New York, NY 10027.
Ken C Q NguyenDepartment of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.
David H HallDepartment of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461.
Martin ChalfieDepartment of Biological Sciences, Columbia University, New York, NY 10027 mc21@columbia.edu.
Columbia University · USAlbert Einstein College of Medicine · US

Funding

Center for C elegans AnatomyR24OD010943 · OD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI DAVID H. HALL, Nathan Schroeder · 2012 to 2026
$9.6M
CENTER FOR CAENORHABDITIS ELGANS ANATOMYR24RR012596 · NCRR · YESHIVA UNIVERSITY · PI HALL, DAVID H. · 1998 to 2011
$8.0M
GENETIC ANALYSIS OF NEMATODE CELL DIFFERENTIATIONR01GM030997 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHALFIE, MARTIN · 1985 to 2017
$7.1M
GENETIC ANALYSIS OF NEMATODE CELL DIFFERENTIATIONR37GM030997 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI CHALFIE, MARTIN · 1999 to 2009
$6.6M
Genetic analysis of nematode cell differentiationR35GM122522 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI MARTIN CHALFIE · 2017 to 2026
$6.5M
Translational Neuroimaging CoreP30HD071593 · NICHD · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI WALKLEY, STEVEN UPSHAW · 2011 to 2015
$5.6M
NCRR NIH HHS R24 RR012596NICHD NIH HHS P30 HD071593NIGMS NIH HHS R01 GM030997NIGMS NIH HHS R35 GM122522NIGMS NIH HHS R37 GM030997NIH HHS R24 OD010943
6 · The paper itself

Abstract

Tubulins, the building block of microtubules (MTs), play a critical role in both supporting and regulating neurite growth. Eukaryotic genomes contain multiple tubulin isotypes, and their missense mutations cause a range of neurodevelopmental defects. Using the

Indexed as

Amino Acid SequenceAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsHumansMicrotubulesMutationNeuritesNeurogenesisNeuronsProtein IsoformsTubulinCaenorhabditis elegans ProteinsProtein IsoformsTubulin

Identifiers

PMID28835377
PMCPMC5638583
OpenAlexW2951244819

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.