Observational studyCardiology in the young2018
Impaired cerebral autoregulation and elevation in plasma glial fibrillary acidic protein level during cardiopulmonary bypass surgery for CHD.
Observational study in Cardiology in the young, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- Cerebral Autoregulation in Non-Brain Injured Patients: A Systematic Review.Frontiers in neurology · 2021Pooled it
- Epigenetic modifications of VEGF, cerebral hypoxia, and impaired cerebrovascular autoregulation as early indicators for preterm brain injury.Function (Oxford, England) · 2026Observational
- Clinical research study: cerebral autoregulation in neonates and infants undergoing open heart surgery: global patterns and derived cerebral hemodynamic metrics.Pediatric research · 2026Observational
- Near-infrared spectroscopy cerebral oximetry in pediatric congenital heart disease with cardiopulmonary bypass: a narrative review of current evidence and neuroprotection.Frontiers in pediatrics · 2026Review
- Impaired Cerebral Autoregulation in Children.Pediatric neurology · 2025Review
- Individualized mean arterial pressure targets in critically ill patients guided by non-invasive cerebral-autoregulation: a scoping review.Critical care (London, England) · 2025Article
- Towards quantitative assessment of cerebrovascular autoregulation in human neonates using ultrafast ultrasound imaging.Scientific reports · 2025Article
- Cerebral autoregulation in pediatric and neonatal intensive care: A scoping review.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2024Article
- How to Define and Meet Blood Pressure Targets After Traumatic Brain Injury: A Narrative Review.Neurocritical care · 2024Review
- Determining Optimal Mean Arterial Blood Pressure Based on Cerebral Autoregulation in Children after Cardiac Surgery.Pediatric cardiology · 2024Article
- Cerebral Autoregulation Status in Relation to Brain Injury on Electroencephalogram and Magnetic Resonance Imaging in Children Following Cardiac Surgery.Journal of the American Heart Association · 2023Observational
- Serum brain injury biomarkers are gestationally and post-natally regulated in non-brain injured neonates.Pediatric research · 2023Observational
- A pilot study: Comparing a novel noninvasive measure of cerebrovascular stability index with an invasive measure of cerebral autoregulation in neonates with congenital heart disease.Journal of clinical and translational science · 2023Article
- Effects of circulatory arrest and cardiopulmonary bypass on cerebral autoregulation in neonatal swine.Pediatric research · 2022Article
- The Utility of Cerebral Autoregulation Indices in Detecting Severe Brain Injury Varies by Cooling Treatment Phase in Neonates with Hypoxic-Ischemic Encephalopathy.Developmental neuroscience · 2022Observational
- Regulation of the Cerebral Circulation During Development.Comprehensive Physiology · 2021Article
- The Relationships of Cerebral and Somatic Oxygen Saturation with Physiological Parameters in Pediatric Cardiac Surgery with Cardiopulmonary Bypass: Analysis Using the Random-Effects Model.Pediatric cardiology · 2021Observational
- Pharmacologic Control of Blood Pressure in Infants and Children.Pediatric cardiology · 2020Review
- Risk Factors for Delayed Neurocognitive Recovery According to Brain Biomarkers and Cerebral Blood Flow Velocity.Medicina (Kaunas, Lithuania) · 2020Observational
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundCerebrovascular reactivity monitoring has been used to identify the lower limit of pressure autoregulation in adult patients with brain injury. We hypothesise that impaired cerebrovascular reactivity and time spent below the lower limit of autoregulation during cardiopulmonary bypass will result in hypoperfusion injuries to the brain detectable by elevation in serum glial fibrillary acidic protein level.
methodsWe designed a multicentre observational pilot study combining concurrent cerebrovascular reactivity and biomarker monitoring during cardiopulmonary bypass. All children undergoing bypass for CHD were eligible. Autoregulation was monitored with the haemoglobin volume index, a moving correlation coefficient between the mean arterial blood pressure and the near-infrared spectroscopy-based trend of cerebral blood volume. Both haemoglobin volume index and glial fibrillary acidic protein data were analysed by phases of bypass. Each patient's autoregulation curve was analysed to identify the lower limit of autoregulation and optimal arterial blood pressure.
resultsA total of 57 children had autoregulation and biomarker data for all phases of bypass. The mean baseline haemoglobin volume index was 0.084. Haemoglobin volume index increased with lowering of pressure with 82% demonstrating a lower limit of autoregulation (41±9 mmHg), whereas 100% demonstrated optimal blood pressure (48±11 mmHg). There was a significant association between an individual's peak autoregulation and biomarker values (p=0.01).
conclusionsIndividual, dynamic non-invasive cerebrovascular reactivity monitoring demonstrated transient periods of impairment related to possible silent brain injury. The association between an impaired autoregulation burden and elevation in the serum brain biomarker may identify brain perfusion risk that could result in injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.