ArticleWorld journal of surgical oncology2017
New trend in colorectal cancer in Germany: are young patients at increased risk for advanced colorectal cancer?
Article in World journal of surgical oncology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Presentation and survival among patients with colorectal cancer before the age of screening: a systematic review and meta-analysis.Canadian journal of surgery. Journal canadien de chirurgie · 2021Pooled it
- Early-Onset Colorectal Cancer in Egypt: Pathological Characters, Patterns of Care, and Survival Compared to Average-Age Onset Colorectal Cancer: A Retrospective Multicenter Study.JCO global oncology · 2024Article
- Family history as a major prerequisite for microsatellite instability screening in colorectal cancer is a poor selection tool.Translational gastroenterology and hepatology · 2024Article
- Microsatellite instability is highly prevalent in older patients with colorectal cancer.Frontiers in surgery · 2024Article
- Different disease characteristics in young patients with colorectal cancer: a large retrospective study in a city in Romania.The Journal of international medical research · 2021Article
- Peritoneal spillage is not an issue in patients undergoing minimally invasive surgery for colorectal cancer.World journal of surgical oncology · 2020Observational
- Young age increases the risk for lymph node metastasis in patients with early Colon Cancer.BMC cancer · 2019Article
- Understanding the impact of socioeconomic differences in colorectal cancer survival: potential gain in life-years.British journal of cancer · 2019Article
- Adenoma and advanced neoplasia detection rates increase from 45 years of age.World journal of gastroenterology · 2019Observational
- Routine preoperative mechanical bowel preparation with additive oral antibiotics is associated with a reduced risk of anastomotic leakage in patients undergoing elective oncologic resection for colorectal cancer.World journal of surgical oncology · 2019Article
- Colorectal Cancer Presentation and Survival in Young Individuals: A Retrospective Cohort Study.Cancers · 2018Article
- Extra nodular metastasis is a poor prognostic factor for overall survival in node-positive patients with colorectal cancer.International journal of colorectal disease · 2018Article
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Abstract
backgroundThe role of colonoscopy in the screening of colorectal cancer (CRC) has been unequivocally established. In Germany, screening colonoscopy with full insurance reimbursement is available for individuals aged 55 and above, and/or for persons with well-known risk factors for CRC. However, advanced CRC is not uncommon in individuals below 55 years. This study was designed to investigate the incidence of advanced CRC in patients < 55 years.
methodsA retrospective analysis of data from a prospectively maintained CRC database of a university hospital in Germany was performed. Using the recommended age for screening colonoscopy as cutoff, the study population was divided into two groups: < 55 years (study group) and ≥ 55 years (control group). Both groups were compared with regard to the extent of CRC using the UICC stages. Only surgically managed patients were included for analysis. Advanced CRC was defined as UICC stage III or IV.
resultsComplete follow-up data was available for 609 patients treated between 2009 and 2013. The study group included 83 patients, 42 females and 41 males with a median age of 48.0 ± 10 years, while the control group was made up of 526 patients, 230 females and 296 males with a median age of 75.5 ± 8.3 years. Both groups were comparable with regard to gender distribution, p = 0.24. Significantly more patients from the study group were diagnosed with advanced CRC in comparison to the control group, 56.6 vs. 43.9%, p = 0.03. There was no statistically significant difference amongst both groups with respect to cancer-related mortality, 10.8 vs. 12.5%, p = 0.66.
conclusionPatients below the recommended age for screening colonoscopy might be at increased risk for advanced CRC. There is need to decrease the recommended age for screening colonoscopy to prevent CRC or enable an early diagnosis in patients below 55 years.
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