Evidence map›Paper›PMID 28835242›Full record

ArticleRetrovirology2017

Granulocytic myeloid-derived suppressor cells suppress virus-specific CD8

Malgorzata Drabczyk-Pluta, Tanja Werner, Daniel Hoffmann, Qibin Leng, Lieping Chen, Ulf Dittmer, Gennadiy Zelinskyy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Retrovirology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Immunometabolism of Myeloid-Derived Suppressor Cells: Implications forInternational journal of molecular sciences · 2022
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Neutrophils in COVID-19.Frontiers in immunology · 2021
    Review
  11. Review
  12. Review
  13. MDSCs in infectious diseases: regulation, roles, and readjustment.Cancer immunology, immunotherapy : CII · 2019
    Review
  14. Article
  15. Article
  16. Article
  17. [Role of programmed death-1 in viral infectious diseases].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2018
    Review
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Malgorzata Drabczyk-PlutaInstitute of Virology, University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Germany.
Tanja WernerInstitute of Virology, University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Germany.
Daniel HoffmannResearch Group Bioinformatics, Faculty of Biology, University of Duisburg-Essen, Essen, Germany.
Qibin LengKey Laboratory of Molecular Virology and Immunology, Institute Pasteur of Shanghai, Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China.
Lieping ChenDepartment of Immunobiology, Yale School of Medicine, Yale University, New Haven, CT, USA.
Ulf DittmerInstitute of Virology, University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Germany.
Gennadiy ZelinskyyInstitute of Virology, University Hospital Essen, University of Duisburg-Essen, Hufelandstraße 55, 45147, Essen, Germany. gennadiy.zelinskyy@uni-due.de.ORCID http://orcid.org/0000-0001-6338-2382

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMyeloid-derived suppressor cells (MDSCs) can suppress T cell responses in several different diseases. Previously these suppressive cells were observed to expand in HIV patients and in a mouse retrovirus model, yet their suppressive effect on virus-specific CD8

resultsWe used the Friend retrovirus (FV) model to demonstrate that MDSCs expand and become activated during the late phase of acute FV infection. Only the subpopulation of granulocytic MDSCs (gMDSCs) but not monocytic MDSC suppressed virus-specific CD8+ T cell proliferation and function in vitro. gMDSCs expressed arginase 1, high levels of the inhibitory ligand PD-L1 and the ATP dephosphorylating enzyme CD39 on the cell surface upon infection. All three molecules were involved in the suppressive effect of the gMDSCs in vitro. MDSC depletion experiments in FV-infected mice revealed that they restrict virus-specific CD8

conclusionsOur study demonstrates that MDSCs become activated and expand during the acute phase of retrovirus infection. Their suppressive activity on virus-specific CD8+ T cells may contribute to T cell dysfunction and the development of chronic infection.

Indexed as

AnimalsAntigens, DifferentiationCD8-Positive T-LymphocytesCell DifferentiationCell ProliferationFriend murine leukemia virusGranulocytesLeukemia, ExperimentalLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutMonocytesMyeloid-Derived Suppressor CellsRetroviridae InfectionsTumor Virus InfectionsAntigens, DifferentiationArginaseCD8+ T cellsFriend virusMDSCPD-L1

Identifiers

PMID28835242
PMCPMC5569525

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.