Evidence map›Paper›PMID 28835220›Full record

ArticleBMC medical imaging2017

Cardiovascular magnetic resonance feature tracking in small animals - a preliminary study on reproducibility and sample size calculation.

Tomas Lapinskas, Jana Grune, Seyedeh Mahsa Zamani, Sarah Jeuthe, Daniel Messroghli, Rolf Gebker, Heike Meyborg, Ulrich Kintscher, Remigijus Zaliunas, Burkert Pieske and 2 more

Abstract read
In one paragraph

Article in BMC medical imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Guidelines for measuring cardiac physiology in mice.American journal of physiology. Heart and circulatory physiology · 2018
    Guideline
  2. Trial
  3. Article
  4. Cardiac Phase-Resolved TBiomedicines · 2025
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Pulmonary arterial banding in mice may be a suitable model for studies on ventricular mechanics in pediatric pulmonary arterial hypertension.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tomas LapinskasDepartment of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Street 2, LT-50161, Kaunas, Lithuania. tomas.lapinskas@lsmuni.lt.ORCID 0000-0001-7726-6948
Jana GruneDepartment of Internal Medicine / Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Seyedeh Mahsa ZamaniDepartment of Internal Medicine / Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Sarah JeutheDepartment of Internal Medicine / Cardiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Daniel MessroghliDepartment of Internal Medicine / Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Rolf GebkerDepartment of Internal Medicine / Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Heike MeyborgDepartment of Internal Medicine / Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Ulrich KintscherCenter for Cardiovascular Research, Institute of Pharmacology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Remigijus ZaliunasDepartment of Cardiology, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Street 2, LT-50161, Kaunas, Lithuania.
Burkert PieskeDepartment of Internal Medicine / Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Philipp StawowyDepartment of Internal Medicine / Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
Sebastian KelleDepartment of Internal Medicine / Cardiology, Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiovascular magnetic resonance feature tracking (CMR-FT) is a novel tissue tracking technique developed for noninvasive assessment of myocardial motion and deformation. This preliminary study aimed to evaluate the observer's reproducibility of CMR-FT in a small animal (mouse) model and define sample size calculation for future trials.

methodsSix C57BL/6 J mice were selected from the ongoing experimental mouse model onsite and underwent CMR with a 3 Tesla small animal MRI scanner. Myocardial deformation was analyzed using dedicated software (TomTec, Germany) by two observers. Left ventricular (LV) longitudinal, circumferential and radial strain (Ell

resultsIn general, Ecc

conclusionsThis pilot study demonstrates good to excellent inter- and intra-observer reproducibility of CMR-FT technique in small animal model. The most reproducible measures are global circumferential and global longitudinal strain, whereas reproducibility of radial strain is weak. Furthermore, sample size calculation demonstrates that a small number of animals could be sufficient for future trials.

Indexed as

AnimalsBody SizeHeart VentriclesMagnetic Resonance Imaging, CineMiceMice, Inbred C57BLObserver VariationPilot ProjectsPredictive Value of TestsReproducibility of ResultsSample SizeSoftwareCardiovascular magnetic resonanceFeature trackingMyocardial strainReproducibilitySmall animal model

Identifiers

PMID28835220
PMCPMC5569535

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.