ArticleCell reports2017
The Proprioceptive System Regulates Morphologic Restoration of Fractured Bones.
Article in Cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Cellular and molecular mechanisms of muscle spindle development and function.Physiology (Bethesda, Md.) · 2026Review
- When broken bones need air: Erythrocytes step in to heal.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Experimental physiology Special Issue: 'Mechanotransduction, muscle spindles and proprioception'.Experimental physiology · 2025Article
- The mechanosensitive ion channel ASIC2 mediates both proprioceptive sensing and spinal alignment.Experimental physiology · 2024Article
- Molecular characterization of the intact mouse muscle spindle using a multi-omics approach.eLife · 2023Article
- Osteoporosis in Light of a New Mechanism Theory of Delayed Onset Muscle Soreness and Non-Contact Anterior Cruciate Ligament Injury.International journal of molecular sciences · 2022Article
- Does Compression Sensory Axonopathy in the Proximal Tibia Contribute to Noncontact Anterior Cruciate Ligament Injury in a Causative Way?-A New Theory for the Injury Mechanism.Life (Basel, Switzerland) · 2021Article
- Muscle spindle function in healthy and diseased muscle.Skeletal muscle · 2021Review
- Piezo2 expressed in proprioceptive neurons is essential for skeletal integrity.Nature communications · 2020Article
- Acetylcholine receptors in the equatorial region of intrafusal muscle fibres modulate mouse muscle spindle sensitivity.The Journal of physiology · 2019Article
- A novel nonosteocytic regulatory mechanism of bone modeling.PLoS biology · 2019Article
- New functions for the proprioceptive system in skeletal biology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Transcriptional Mechanisms of Secondary Fracture Healing.Current osteoporosis reports · 2018Review
- Mechanical regulation of musculoskeletal system development.Development (Cambridge, England) · 2017Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Successful fracture repair requires restoration of bone morphology and mechanical integrity. Recent evidence shows that fractured bones of neonatal mice undergo spontaneous realignment, dubbed "natural reduction." Here, we show that natural reduction is regulated by the proprioceptive system and improves with age. Comparison among mice of different ages revealed, surprisingly, that 3-month-old mice exhibited more rapid and effective natural reduction than newborns. Fractured bones of null mutants for transcription factor Runx3, lacking functional proprioceptors, failed to realign properly. Blocking Runx3 expression in the peripheral nervous system, but not in limb mesenchyme, recapitulated the null phenotype, as did inactivation of muscles flanking the fracture site. Egr3 knockout mice, which lack muscle spindles but not Golgi tendon organs, displayed a less severe phenotype, suggesting that both receptor types, as well as muscle contraction, are required for this regulatory mechanism. These findings uncover a physiological role for proprioception in non-autonomous regulation of skeletal integrity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.