Evidence map›Paper›PMID 28834610›Full record

ArticleJournal of cellular physiology2018

Nestin expression is dynamically regulated in cardiomyocytes during embryogenesis.

Vanessa Hertig, Adrianna Matos-Nieves, Vidu Garg, Louis Villeneuve, Maya Mamarbachi, Laurie Caland, Angelino Calderone

Abstract read
In one paragraph

Article in Journal of cellular physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. NestinJournal of cellular physiology · 2025
    Article
  4. Article
  5. Distribution, contribution and regulation of nestinJournal of advanced research · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. The Biological Role of NestinFrontiers in cell and developmental biology · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Vanessa HertigResearch Center, Montreal Heart Institute and Université de Montréal, Montréal, Québec, Canada.
Adrianna Matos-NievesCenter for Cardiovascular Research and the Heart Center, Nationwide Children's Hospital, OH Department of Pediatrics, The Ohio State University, OH Department of Molecular Genetics, The Ohio State University, Columbus, Ohio.
Vidu GargCenter for Cardiovascular Research and the Heart Center, Nationwide Children's Hospital, OH Department of Pediatrics, The Ohio State University, OH Department of Molecular Genetics, The Ohio State University, Columbus, Ohio.
Louis VilleneuveResearch Center, Montreal Heart Institute and Université de Montréal, Montréal, Québec, Canada.
Maya MamarbachiResearch Center, Montreal Heart Institute and Université de Montréal, Montréal, Québec, Canada.
Laurie CalandResearch Center, Montreal Heart Institute and Université de Montréal, Montréal, Québec, Canada.
Angelino CalderoneResearch Center, Montreal Heart Institute and Université de Montréal, Montréal, Québec, Canada.ORCID 0000-0002-4170-5950
Montreal Heart Institute · CANationwide Children's Hospital · US

Funding

Genetic Regulation of Cardiac SeptationR01HL088965 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GARG, VIDU · 2007 to 2011
$1.9M
NHLBI NIH HHS R01 HL088965
6 · The paper itself

Abstract

The transcriptional factors implicated in the expression of the intermediate filament protein nestin in cardiomyocytes during embryogenesis remain undefined. In the heart of 9,5-10,5 day embryonic mice, nestin staining was detected in atrial and ventricular cardiomyocytes and a subpopulation co-expressed Tbx5. At later stages of development, nestin immunoreactivity in cardiomyocytes gradually diminished and was absent in the heart of 17,5 day embryonic mice. In the heart of wild type 11,5 day embryonic mice, 54 ± 7% of the trabeculae expressed nestin and the percentage was significantly increased in the hearts of Tbx5

Indexed as

Embryonic DevelopmentAnimalsAnimals, NewbornCell CycleCell NucleusEmbryo, MammalianGATA4 Transcription FactorHeterozygoteImidazolesMice, Inbred C57BLMuscle, SkeletalMyocardiumMyocytes, CardiacNestinp38 Mitogen-Activated Protein KinasesPyridinesGATA4 Transcription FactorImidazolesNestinp38 Mitogen-Activated Protein KinasesPyridinesSB 203580T-Box Domain ProteinsT-box transcription factor 5cardiomyocytesembryogenesisGATA4nestinTBX5Yap-1

Identifiers

PMID28834610
PMCPMC5783184
OpenAlexW2745810305

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.