Evidence map›Paper›PMID 28834365›Full record

ArticleAndrology2017

Spontaneous testicular atrophy occurs despite normal spermatogonial proliferation in a Tp53 knockout rat.

Matthew S Dai, Susan J Hall, Marguerite M Vantangoli Policelli, Kim Boekelheide, Daniel J Spade

Open access · greenAbstract read
In one paragraph

Article in Andrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. The lncRNA Gm8097 is associated with hypospermatogenesis.Clinical and experimental reproductive medicine · 2024
    Article
  3. The role of p53 in male infertility.Frontiers in endocrinology · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Matthew S DaiDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Susan J HallDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Marguerite M Vantangoli PolicelliDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Kim BoekelheideDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.
Daniel J SpadeDepartment of Pathology and Laboratory Medicine, Brown University, Providence, RI, USA.ORCID 0000-0002-4694-8724
Brown University · US

Funding

TRAINING IN ENVIRONMENTAL PATHOLOGYT32ES007272 · NIEHS · BROWN UNIVERSITY · PI ZHITKOVICH, ANATOLY · 1992 to 2021
$7.5M
Molecular Mechanism of Human Fetal Testis Susceptibility to Endocrine DisruptionR01ES017272 · NIEHS · BROWN UNIVERSITY · PI BOEKELHEIDE, KIM · 2010 to 2014
$2.7M
Retinoic Acid Signaling Disruption by Phthalates in Human and Rodent Fetal TestisK99ES025231 · NIEHS · BROWN UNIVERSITY · PI SPADE, DANIEL JAMES · 2016 to 2017
$200k
NIEHS NIH HHS K99 ES025231NIEHS NIH HHS R01 ES017272NIEHS NIH HHS T32 ES007272
6 · The paper itself

Abstract

The tumor suppressor protein p53 (TP53) has many functions in cell cycle regulation, apoptosis, and DNA damage repair and is also involved in spermatogenesis in the mouse. To evaluate the role of p53 in spermatogenesis in the rat, we characterized testis biology in adult males of a novel p53 knockout rat (SD-Tp53

Indexed as

AnimalsAtrophyCell ProliferationGene Knockout TechniquesMaleRatsRats, Sprague-DawleySpermatogenesisSpermatogoniaTestisTumor Suppressor Protein p53Tumor Suppressor Protein p53germ cell deathp53spermatogenesis

Identifiers

PMID28834365
PMCPMC5673550
OpenAlexW2749149189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.