ArticleAngewandte Chemie (International ed. in English)2017
Electrochemically Enabled, Nickel-Catalyzed Amination.
Article in Angewandte Chemie (International ed. in English), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers.
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Who cites it
70 citing papers in PubMed.
- Base-Free C-N Cross-Electrophile Coupling.Journal of the American Chemical Society · 2026Article
- Review
- Nickel-Catalyzed Aminocarbonylation of Aryl Trifluoromethoxides.Organic letters · 2026Article
- Paired electrolysis enables para-C-H amination of phenols with nitroarenes and mechanistic visualization via multifunctional electrochemical mass spectrometry.Nature communications · 2026Article
- Recent Advancements in Nickel-Catalyzed Electrochemical Reductive Cross-Coupling.ACS organic & inorganic Au · 2025Review
- Deciphering the Synchronization of Alternating Current Frequency with the Nickel Catalytic Cycle in Selective C-N Cross-Coupling.Journal of the American Chemical Society · 2025Article
- Electrochemically promoted defluorinative sulfoximination and fluorosulfonylation of non-activated aryl fluorides at room temperature.Chemical science · 2025Article
- Photoelectrochemistry-Promoted Ni-Catalyzed C-O Cross-Couplings.Precision chemistry · 2025Article
- Indole Photocatalysts and Secondary Amine Ligands Enable Nickel-Photoredox C(spACS catalysis · 2025Article
- Nickel-mediated aerobic C(sp2)-nucleophile coupling reactions for late-stage diversification of aryl electrophiles.Nature synthesis · 2025Article
- Cross-Coupling Reactions with Nickel, Visible Light, andACS catalysis · 2025Article
- An Automated Electrochemical Flow Platform to Accelerate Library Synthesis and Reaction Optimization.Angewandte Chemie (International ed. in English) · 2024Article
- Photoelectrochemical Ni-catalyzed cross-coupling of aryl bromides with amine at ultra-low potential.Nature communications · 2024Article
- "Naked Nickel"-Catalyzed Amination of Heteroaryl Bromides.Organic letters · 2024Article
- The development of cage phosphine 'DalPhos' ligands to enable nickel-catalyzed cross-couplings of (hetero)aryl electrophiles.Chemical science · 2024Review
- Electrosynthesis of iminophosphoranes and applications in nickel catalysis.Chemical science · 2024Article
- Metal-ligand cooperativity in chemical electrosynthesis.Chem catalysis · 2024Article
- Article
- A review of recent advances in electrochemical and photoelectrochemical late-stage functionalization classified by anodic oxidation, cathodic reduction, and paired electrolysis.Beilstein journal of organic chemistry · 2024Review
- Temperature-Dependent Spontaneous Resolution of a Tetrahedral Chiral-at-Nickel(II) Complex under Supramolecular Control.ACS organic & inorganic Au · 2023Article
10 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
Abstract
Along with amide bond formation, Suzuki cross-coupling, and reductive amination, the Buchwald-Hartwig-Ullmann-type amination of aryl halides stands as one of the most employed reactions in modern medicinal chemistry. The work herein demonstrates the potential of utilizing electrochemistry to provide a complementary avenue to access such critical bonds using an inexpensive nickel catalyst under mild reaction conditions. Of note is the scalability, functional-group tolerance, rapid rate, and the ability to employ a variety of aryl donors (Ar-Cl, Ar-Br, Ar-I, Ar-OTf), amine types (primary and secondary), and even alternative X-H donors (alcohols and amides).
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