ArticleCell proliferation2017
Induction of retinal-dependent calcium influx in human melanocytes by UVA or UVB radiation contributes to the stimulation of melanosome transfer.
Article in Cell proliferation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- IP3R2-mediated inter-organelle calcium signaling suppresses melanosome degradation.PLoS biology · 2026Article
- TRP Channels in Skin Cancer: Focus on Malignant Melanoma.International journal of molecular sciences · 2025Review
- Involvement of interferon γ-producing mast cells in immune responses against melanocytes in vitiligo requires Mas-related G protein-coupled receptor X2 activation.Chinese medical journal · 2025Article
- Photo-neuro-immuno-endocrinology: How the ultraviolet radiation regulates the body, brain, and immune system.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Hydrolyzed Conchiolin Protein (HCP) Extracted from Pearls Antagonizes both ET-1 andInternational journal of molecular sciences · 2023Article
- Opsin 3 mediates UVA-induced keratinocyte supranuclear melanin cap formation.Communications biology · 2023Article
- Biology of melanocytes in mammals.Frontiers in cell and developmental biology · 2023Review
- Vitamin A in Skin and Hair: An Update.Nutrients · 2022Review
- Review
- sPmel17 Secreted by Ultraviolet B-Exposed Melanocytes Alters the Intercellular Adhesion of Keratinocytes.Oxidative medicine and cellular longevity · 2022Article
- Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation.Antioxidants (Basel, Switzerland) · 2021Review
- Opsin 5 is a key regulator of ultraviolet radiation-induced melanogenesis in human epidermal melanocytes.The British journal of dermatology · 2021Article
- Role of the p53‑TRPM1/miR‑211‑MMP9 axis in UVB‑induced human melanocyte migration and its potential in repigmentation.International journal of molecular medicine · 2020Article
- miR-122 Inhibits Hepatocarcinoma Cell Progression by Targeting LMNB2.Oncology research · 2020Article
- Research Techniques Made Simple: Cell Biology Methods for the Analysis of Pigmentation.The Journal of investigative dermatology · 2020Review
- Opsin3 Downregulation Induces Apoptosis of Human Epidermal Melanocytes via Mitochondrial Pathway.Photochemistry and photobiology · 2020Article
- Illuminating insights into opsin 3 function in the skin.Advances in biological regulation · 2020Review
- Effects and Mechanism of Nicotinamide Against UVA- and/or UVB-mediated DNA Damages in Normal Melanocytes.Photochemistry and photobiology · 2019Article
- How UV Light Touches the Brain and Endocrine System Through Skin, and Why.Endocrinology · 2018Review
- Degraded melanocores are incompetent to protect epidermal keratinocytes against UV damage.Cell cycle (Georgetown, Tex.) · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe transfer of melanosomes from melanocytes to neighbouring keratinocytes is critical to protect the skin from the deleterious effects of ultraviolet A (UVA) and ultraviolet B (UVB) irradiation; however, the initial factor(s) that stimulates melanosome transfer remains unclear. In this study, we investigated the induction of retinal-dependent calcium (Ca MATERIALS AND
methodsPrimary human epidermal MCs were exposed to physiological doses of UVB or UVA light and loaded with a calcium indicator Fluo-4 dye. The change of intracellular calcium of MCs was monitored using a two-photon confocal fluorescence microscopy. MCs were co-cultured with human epidermal keratinocytes (KCs) in the absence or presence of voriconazole (a TRPM1 blocker) or calcium chelators. MCs were also transfected with TRPM1 siRNA for silencing the expression of TRPM1 gene. The melanosome transfer in the co-cultured cells was quantitatively analysed using flow cytometry and was further confirmed by immunofluorescent double-staining. The protein levels and distributions of TRPM1, OPN3 and OPN5 in MCs were measured by Western blotting or immunofluorescent staining.
resultsThe retinal-dependent Ca
conclusionsThe distinct time-phases of Ca
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.