ArticleEuropean journal of oral sciences2017
Impaired polymorphonuclear neutrophils in the oral cavity of edentulous individuals.
Article in European journal of oral sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Decreased GCF DEL-1 and increased GCF neutrophils with increasing probing pocket depth.Journal of periodontal & implant science · 2024Article
- Association of neutrophil defects with oral ulcers but undetermined role of neutrophils in recurrent aphthous stomatitis.Heliyon · 2024Review
- Human oral mucosa and oral microbiome interactions following supragingival plaque reconstitution in healthy volunteers: a diet-controlled balanced design proof-of-concept model to investigate oral pathologies.Journal of oral microbiology · 2023Article
- Innate Phagocyte Polarization in the Oral Cavity.Frontiers in immunology · 2021Review
- The Neutrophil: Constant Defender and First Responder.Frontiers in immunology · 2020Review
- Oral Neutrophils: Underestimated Players in Oral Cancer.Frontiers in immunology · 2020Review
- Chemotherapy-induced oral mucositis is associated with detrimental bacterial dysbiosis.Microbiome · 2019Observational
- The Possible Role of Neutrophils in the Induction of Osteoclastogenesis.Journal of immunology research · 2019Article
- Oral Neutrophils Characterized: Chemotactic, Phagocytic, and Neutrophil Extracellular Trap (NET) Formation Properties.Frontiers in immunology · 2019Article
- Neutrophil Subsets in Periodontal Health and Disease: A Mini Review.Frontiers in immunology · 2019Review
- Characterization of oral polymorphonuclear neutrophils in periodontitis patients: a case-control study.BMC oral health · 2018Article
- Oral Polymorphonuclear Neutrophil Contributes to Oral Health.Current oral health reports · 2018Review
- Impaired polymorphonuclear neutrophils in the oral cavity of edentulous individuals.European journal of oral sciences · 2017Article
- Neutrophils defending the defenders.Journal of oral and maxillofacial pathology : JOMFPReview
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral health is characterized by functional oral polymorphonuclear neutrophils (oPMNs). Edentulism might be associated with a loss of oPMNs because these cells enter the oral cavity primarily through the gingival crevices. The main aim of this study was to investigate the numbers of oPMNs in rinse samples obtained from edentulous (n = 21) and dentate (n = 20) subjects. A second study aim was to investigate possible differences between oPMNs and peripheral blood polymorphonuclear neutrophils (cPMNs). Apoptosis/necrosis and cell-activation markers (CD11b, CD63 and CD66b) were analyzed using flow cytometry. Reactive oxygen species (ROS) production was determined either without stimulation (constitutive) or in response to 10 μM phorbol myristate acetate or Fusobacterium nucleatum. The edentulous subjects presented with lower oPMN counts and higher percentages of apoptotic/necrotic oPMNs compared with dentate subjects. Furthermore, oPMNs from edentulous donors expressed low levels of all three activation markers and low constitutive ROS. In contrast, oPMNs from dentate subjects expressed high levels of all three activation markers and a higher level of constitutive ROS than cPMNs. When challenged, oPMNs from edentulous subjects showed no upregulation in ROS production, whereas oPMNs from dentate subjects retained their ability to respond to stimulation. The functional characteristics of cPMNs were comparable between edentulous and dentate subjects. This study demonstrates that despite having functional cPMNs, edentulous subjects have low oPMN numbers that are functionally impaired.
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