ArticleAddiction (Abingdon, England)2018
Effects of high alcohol intake, alcohol-related symptoms and smoking on mortality.
Article in Addiction (Abingdon, England), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
13 citing papers in PubMed.
- Alcohol consumption reported on routine healthcare screenings is associated with all-cause mortality in primary care patients: A retrospective cohort study.Alcohol, clinical & experimental research · 2025Article
- Alcohol Misuse, Binge Drinking, and their Associations with Psychosocial Factors during COVID-19 among Harlem Residents in New York City.Journal of urban health : bulletin of the New York Academy of Medicine · 2023Article
- Unraveling the roles of excessive alcohol use and liver disease in mortality.Alcohol, clinical & experimental research · 2023Article
- All-cause and liver-related mortality risk factors in excessive drinkers: Analysis of data from the UK biobank.Alcoholism, clinical and experimental research · 2022Article
- For whom the bell tolls: psychopathological and neurobiological correlates of a DNA methylation index of time-to-death.Translational psychiatry · 2022Article
- Shared Genetic Etiology between Cortical Brain Morphology and Tobacco, Alcohol, and Cannabis Use.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Mortality and Alcohol as Its Cause-Comparative Characteristics of the Two Neighboring Countries: Ukraine and Poland.International journal of environmental research and public health · 2021Article
- Long-term excess mortality after chronic subdural hematoma.Acta neurochirurgica · 2020Article
- The presence of chronic diseases contributes to the occurrence risk factors for gynecological cancers in Japan.Molecular and clinical oncology · 2020Article
- A Pilot Follow-Up Study of Older Alcohol-Dependent COGA Adults.Alcoholism, clinical and experimental research · 2019Article
- Psychiatric comorbidity as a risk factor for the mortality of people with bulimia nervosa.Social psychiatry and psychiatric epidemiology · 2019Article
- Psychiatric comorbidity as a risk factor for mortality in people with anorexia nervosa.European archives of psychiatry and clinical neuroscience · 2019Article
- Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.Alcoholism, clinical and experimental research · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
BACKGROUND AND
aimsBoth high alcohol intake and alcohol dependence increase mortality, and both are associated with smoking. We aimed to compare the associations of quantity of alcohol, number of alcohol-related symptoms and smoking history with all-cause mortality, and to assess symptom count and smoking history as confounders or mediators of the effects of high alcohol intake.
designSurvival was analysed by Cox regression with sex, body mass index, alcohol intake (overall and by beverage), maximum drinks on any day, alcohol symptom count and smoking status as potential predictors of age at death.
settingAustralia.
participantsParticipants were apparently healthy volunteers consisting of 33 593 Australian adult twins and their relatives who completed questionnaires or interviews between 1979 and 2005. MEASUREMENTS: Data on alcohol use, smoking and occurrence of symptoms related to alcohol use disorders and death records from the Australian National Death Index.
findingsA total of 3764 participants were matched with deaths occurring within Australia up to July 2014. Individually, alcohol intake [hazard ratio (HR) = 1.0082, 95% confidence interval (CI) = 1.0063-1.0102, per drink per week], beer intake (HR = 1.0159, 95% CI = 1.0123-1.0195, per drink per week), life-time maximum number of drinks in 1 day (HR = 1.0176, 95% CI = 1.0130-1.0221, per drink), symptom count (HR = 1.0867, 95% CI = 1.0633-1.1106, per symptom) and smoking status (HR = 2.82, 95% CI = 2.52-3.16 for smokers of 10+ cigarettes/day versus never-smokers) were each significant predictors of all-cause mortality. After adjustment for the independently significant predictors alcohol symptom count and smoking status, alcohol intake was no longer significant (adjusted HR = 1.0012 per drink per week, 95% CI = 0.9979-1.0145).
conclusionsNumber of symptoms related to high alcohol intake and tobacco smoking appear to account for the positive association between alcohol consumption and premature mortality.
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