ArticleInternational journal of geriatric psychiatry2018
The association of antidepressant treatment with COPD maintenance medication use and adherence in a comorbid Medicare population: A longitudinal cohort study.
Article in International journal of geriatric psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Methods to assess COPD medications adherence in healthcare databases: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- Prevalence and predictors of medication non-adherence among people living with multimorbidity: a systematic review and meta-analysis.BMJ open · 2021Pooled it
- The Relationship Between Anxiety, Depression and Treatment Adherence in Chronic Obstructive Pulmonary Disease: A Systematic Review.International journal of chronic obstructive pulmonary disease · 2021Pooled it
- Association between comorbid depression, antidepressant adherence, and disease-modifying therapy adherence among Texas Medicaid patients with sickle cell disease.Journal of managed care & specialty pharmacy · 2026Article
- Depression and Anxiety as Comorbidities in Chronic Obstructive Pulmonary Disease: A Comprehensive Narrative Review.Healthcare (Basel, Switzerland) · 2025Review
- Nationwide Trends and Outcomes of Alcohol Use Disorders in COPD Hospitalizations in Spain, 2016-2023.Journal of clinical medicine · 2025Article
- Psychiatric Disorders in Patients with Chronic Obstructive Pulmonary Disease: Clinical Significance and Treatment Strategies.Journal of clinical medicine · 2024Review
- Association between trajectories of adherence to endocrine therapy and risk of treated breast cancer recurrence among US nonmetastatic breast cancer survivors.British journal of cancer · 2024Article
- Trends, characteristics, race, and ethnicity associated with nonadherence to antidepressants among breast cancer survivors with depression.Journal of managed care & specialty pharmacy · 2023Article
- Prediction of treatment nonadherence among older adults with chronic obstructive pulmonary disease using Medicare real-world data.Journal of managed care & specialty pharmacy · 2022Article
- Benefit-Risk Assessment of Psychotropic Drugs in Older Patients with Chronic Obstructive Pulmonary Disease.Drugs & aging · 2022Review
- Interventions for Adherence Improvement in the Primary Prevention of Cardiovascular Diseases: Expert Consensus Statement.Korean circulation journal · 2022Review
- Prevalence and Determinants of Mental Health among COPD Patients in a Population-Based Sample in Spain.Journal of clinical medicine · 2021Article
- Medication adherence among patients with chronic obstructive pulmonary disease treated in a primary general hospital during the COVID-19 pandemic.Annals of translational medicine · 2020Article
- Symptoms of anxiety and depression and use of anxiolytic-hypnotics and antidepressants in current and former smokers with and without COPD - A cross sectional analysis of the COPDGene cohort.Journal of psychosomatic research · 2019Article
- Medication management patterns among Medicare beneficiaries with chronic obstructive pulmonary disease who initiate nebulized arformoterol treatment.International journal of chronic obstructive pulmonary disease · 2019Observational
- New insights to improve treatment adherence in asthma and COPD.Patient preference and adherence · 2019Article
- Nonadherence to treatment and quality of life among patients with chronic obstructive pulmonary disease.Lung India : official organ of Indian Chest SocietyArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
The effect of treating comorbid depression to achieve optimal management of chronic obstructive pulmonary disease (COPD) has not yet empirically tested. We examined the association between antidepressant treatment and use of and adherence to COPD maintenance medications among patients with new-onset COPD and comorbid depression.
methodsUsing 2006-2012 Medicare data, this retrospective cohort study identified patients with newly diagnosed COPD and new-onset major depression. Two exposures-antidepressant use (versus non-use) and adherence measured by proportion of days covered (PDC) (PDC ≥0.8 versus <0.8)-were assessed quarterly. We used marginal structural models to estimate the effects of prior antidepressant use and adherence on subsequent COPD maintenance inhaler use and adherence outcomes, accounting for time-varying confounders.
resultsA total of 25 458 COPD-depression patients, 82% with antidepressant treatment, were followed for a median of 2.5 years. Nearly half (48%) used at least 1 COPD maintenance inhaler in any given quarter; among users, 3 in 5 (61%) had a PDC of <0.8. Compared to patients with no antidepressant treatment, those with antidepressant use were more likely to use (relative ratio [RR] = 1.15, 95% confidence interval [CI] = 1.12- 1.17) and adhere to (RR = 1.08, 95% = 1.03-1.14) their COPD maintenance inhalers. Patients who adhered to antidepressant treatment were more likely to use and adhere to COPD maintenance inhalers.
conclusionRegularly treated depression may increase use of and adherence to necessary maintenance medications for COPD. Antidepressant treatment may be a key determinant to improving medication-taking behaviors among COPD patients comorbid with depression.
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