ArticleMagnetic resonance in medicine2018
A chemical shift encoding (CSE) approach for spectral selection in fluorine-19 MRI.
Article in Magnetic resonance in medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 11 citations in OpenAlex.
- Radial Hadamard-encodedMagma (New York, N.Y.) · 2025Article
- A stable, highly concentrated fluorous nanoemulsion formulation for in vivo cancer imaging viaNMR in biomedicine · 2024Article
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- An iterative sparse deconvolution method for simultaneous multicolorMagnetic resonance in medicine · 2020Article
- Improved compressed sensing reconstruction forMagma (New York, N.Y.) · 2019Article
- Chemical shift encoding (CSE) for sensitive fluorine-19 MRI of perfluorocarbons with complex spectra.Magnetic resonance in medicine · 2018Article
- An open source, 3D printed preclinical MRI phantom for repeated measures of contrast agents and reference standards.Biomedical physics & engineering express · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo develop a chemical shift encoding (CSE) approach for fluorine-19 MRI of perfluorocarbons in the presence of multiple known fluorinated chemical species. THEORY AND
methodsA multi-echo CSE technique is applied for spectral separation of the perfluorocarbon perfluoro-15-crown-5-ether (PFCE) and isoflurane (ISO) based on their chemical shifts at 4.7 T. Cramér-Rao lower bound analysis is used to identify echo combinations with optimal signal-to-noise performance. Signal contributions are fit with a multispectral fluorine signal model using a non-linear least squares estimation reconstruction directly from k-space data. This CSE approach is tested in fluorine-19 phantoms and in a mouse with a 2D and 3D spoiled gradient-echo acquisition using multiple echo times determined from Cramér-Rao lower bound analysis.
resultsCramér-Rao lower bound analysis for PFCE and ISO separation shows signal-to-noise performance is maximized with a 0.33 ms echo separation. A linear behavior (R
conclusionFeasibility of a gradient-echo CSE acquisition and image reconstruction approach with optimized noise performance is demonstrated through fluorine-19 MRI of PFCE with effective removal of ISO signal contributions. Magn Reson Med 79:2183-2189, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
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