Evidence map›Paper›PMID 28833046›Full record

ArticleEuropean journal of immunology2017

AhR activation increases IL-2 production by alloreactive CD4

Allison K Ehrlich, Jamie M Pennington, Susan Tilton, Xisheng Wang, Nikki B Marshall, Diana Rohlman, Castle Funatake, Sumit Punj, Edmond O'Donnell, Zhen Yu and 2 more

Open access · bronzeAbstract read
In one paragraph

Article in European journal of immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 37 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. [DNAM-1 regulates the proliferation and function of T regulatory type 1 cellsNan fang yi ke da xue xue bao = Journal of Southern Medical University · 2022
    Article
  14. The absence of AhR in CD4Clinical epigenetics · 2022
    Article
  15. Immune phenotype of the CD4GeroScience · 2022
    Article
  16. Review
  17. Article
  18. Article
  19. IL-2 regulates tumor-reactive CD8Nature immunology · 2021
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Allison K EhrlichDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
Jamie M PenningtonDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
Susan TiltonDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
Xisheng WangDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
Nikki B MarshallDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
Diana RohlmanDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
Castle FunatakeDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
Sumit PunjDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
Edmond O'DonnellDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
Zhen YuDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
Siva K KolluriDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.
Nancy I KerkvlietDepartment of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, USA.ORCID 0000-0002-4618-8112
Oregon State University · USAlbert Einstein College of Medicine · US

Funding

Reducing Susceptibility to Environmental Stress Throughout the Life SpanP30ES000210 · NIEHS · OREGON STATE UNIVERSITY · PI BECKMAN, JOSEPH S · 1985 to 2015
$21.4M
MODE OF ACTION OF ENVIRONMENTAL TOXICANTST32ES007060 · NIEHS · OREGON STATE UNIVERSITY · PI Jamie DeWitt, Siva Kumar Kolluri · 1985 to 2026
$11.6M
TOXICOLOGY OF ENVIRONMENTAL HALOCARBONSP01ES000040 · NIEHS · OREGON STATE UNIVERSITY · PI BECKMAN, JOSEPH S · 1985 to 2007
$8.0M
The AHR as a Novel Pathway to the Induction of Regulatory T cellsR01ES016651 · NIEHS · OREGON STATE UNIVERSITY · PI KERKVLIET, NANCY I · 2009 to 2017
$3.5M
NIEHS NIH HHS P01ES00210NIEHS NIH HHS P30 ES000210NIEHS NIH HHS R01 ES016651NIEHS NIH HHS T32 ES007060
6 · The paper itself

Abstract

Activation of the aryl hydrocarbon receptor (AhR) by immunosuppressive ligands promotes the development of regulatory T (Treg) cells. Although AhR-induced Foxp3

Indexed as

AllograftsAnimalsCD4-Positive T-LymphocytesCell DifferentiationCell MovementInterleukin-2Intestinal MucosaLymphocyte ActivationMiceMice, Inbred C57BLMice, TransgenicReceptors, Aryl HydrocarbonT-Lymphocytes, RegulatoryInterleukin-2Receptors, Aryl HydrocarbonAhRCD4+ T cellsIL-2Lag3MigrationTim3Tr1 cells

Identifiers

PMID28833046
PMCPMC5927372
OpenAlexW2749288256

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.