ReviewActa psychiatrica Scandinavica2017
Infectious and immunogenetic factors in bipolar disorder.
Review in Acta psychiatrica Scandinavica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 50 citations in OpenAlex.
- Immune dysregulation in mania: A proof-of-concept platelet proteomics study.Psychiatry and clinical neurosciences · 2026Article
- Dissecting the genetic relationship between severe mental disorders and autoimmune diseases.Brain, behavior, and immunity · 2026Article
- Peripheral complement C3 and C4 are associated with clinical features of schizophrenia.Frontiers in psychiatry · 2026Article
- The relationship between polyunsaturated fatty acids and inflammation: evidence from cohort and Mendelian randomization analyses.International journal of epidemiology · 2025Article
- Investigating the frequency of tick-borne infections in a case series of 37 youth diagnosed with pediatric bipolar disorder.Frontiers in child and adolescent psychiatry · 2025Article
- Integrating human endogenous retroviruses into transcriptome-wide association studies highlights novel risk factors for major psychiatric conditions.Nature communications · 2024Article
- Increased Serum Terminal Complements Complex Levels in Attention Deficit Hyperactivity Disorder Children.Iranian journal of medical sciences · 2024Article
- Comparison of the stability of glycoprotein acetyls and high sensitivity C-reactive protein as markers of chronic inflammation.Immunology · 2024Review
- Multiple morbidities are associated with serious infections in patients with rheumatoid arthritis.Seminars in arthritis and rheumatism · 2024Article
- Genetic evidence for causal effects of immune dysfunction in psychiatric disorders: where are we?Translational psychiatry · 2024Review
- Causal role of immune cells in bipolar disorder: a Mendelian randomization study.Frontiers in psychiatry · 2024Article
- Natural killer (NK) cells in bipolar disorders.Neuroscience applied · 2024Review
- Examining the Relationships between the Incidence of Infectious Diseases and Mood Disorders: An Analysis of Data from the Global Burden of Disease Studies, 1990-2019.Diseases (Basel, Switzerland) · 2023Article
- T cells: an emerging cast of roles in bipolar disorder.Translational psychiatry · 2023Review
- Schizophrenia, Human Leukocyte Antigen (HLA), and Herpes Viruses: Immunogenetic Associations at the Population Level.Neuroscience insights · 2023Article
- Article
- Virus-Induced Maternal Immune Activation as an Environmental Factor in the Etiology of Autism and Schizophrenia.Frontiers in neuroscience · 2022Review
- Natural killer cells in first-episode psychosis: an innate immune signature?Molecular psychiatry · 2021Article
- DNA hydrolysing IgG catalytic antibodies: an emerging link between psychoses and autoimmunity.NPJ schizophrenia · 2021Article
- Ensuring mental health care during the SARS-CoV-2 epidemic in France: A narrative review.L'Encephale · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDespite the evidence supporting the association between infection and bipolar disorder (BD), the genetic vulnerability that mediates its effects has yet to be clarified. A genetic origin for the immune imbalance observed in BD, possibly involved in the mechanisms of pathogen escape, has, however, been suggested in recent studies.
methodHere, we present a critical review based on a systematic literature search of articles published until December 2016 on the association between BD and infectious/immunogenetic factors.
resultsWe provide evidence suggesting that infectious insults could act as triggers of maladaptive immune responses in BD and that immunogenetic vulnerability may amplify the effects of such environmental risk factors, increasing susceptibility to subsequent environmental encounters. Quality of evidence was generally impaired by scarce attempt of replication, small sample sizes and lack of high-quality environmental measures.
conclusionInfection has emerged as a potential preventable cause of morbidity in BD, urging the need to better investigate components of the host-pathogen interaction in patients and at-risk subjects, and thus opening the way to novel therapeutic opportunities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.