Evidence map›Paper›PMID 28832760›Full record

SynthesisBrazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica2017

Meta-analysis of the association between PADI4 -92C/G polymorphism and rheumatoid arthritis in the Chinese population.

Z Y Guo, J X Zhang, M Wu, Y F Mei, X J Lin, C Bu, Y Xie, J Wang

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Z Y GuoDepartment of Orthopedic Surgery, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
J X ZhangDepartment of Orthopedic Surgery, Qingtian People Hospital (The Affiliated Hospital of Lishui Academy), Qingtian, China.
M WuDepartment of Combine of Western Medicine and Traditional Chinese Medicine, Sanmen People Hospital, Sanmen, China.
Y F MeiDepartment of Orthopedic Surgery, Sanmen People Hospital, Sanmen, China.
X J LinDepartment of Orthopedic Surgery, The First Affiliated Hospital of Zhejiang University, Hangzhou, China.
C BuInstitute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
Y XieInstitute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
J WangInstitute of Virology and Biotechnology, Zhejiang Academy of Agricultural Sciences, Hangzhou, China.
ZheJiang Academy of Agricultural Sciences · CNFirst Affiliated Hospital Zhejiang University · CNFirst People’s Hospital of Jingmen · CNGuang’anmen Hospital · CNQingzhou City People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Many studies have evaluated the correlation between peptidylarginine deiminase 4 (PADI4) -92C/G polymorphism and rheumatoid arthritis (RA), but the results remain inconclusive. Therefore, we performed a meta-analysis in the Chinese population to provide comprehensive data on the association between PADI4 -92C/G polymorphism and RA. Eligible studies published before May 2016 were identified in PubMed and Chinese databases. The strengths of these associations were assessed by pooled odds ratios (OR) and 95% confidence interval (CI). Eight studies documenting a total of 1351 RA cases and 1585 controls were included in this meta-analysis. In the overall analysis, a significant association between the PADI4 -92C/G polymorphism and RA was found in the Chinese population (G vs C: OR=1.32, 95%CI=1.02-1.71; GG+CG vs CC: OR=1.75, 95%CI=1.20-2.53). The subgroup analyses stratified by geographic area(s) and source of controls revealed significant results in South China, in hospital-based studies and population-based studies. In summary, this meta-analysis suggested that PADI4 -92C/G polymorphism may be associated with the RA incidence in the Chinese population, especially for South China. Further studies conducted on other ethnic groups are required for definite conclusions.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideArthritis, RheumatoidChinaConfidence IntervalsHumansOdds RatioProtein-Arginine DeiminasesProtein-Arginine Deiminase Type 4Risk FactorsPADI4 protein, humanProtein-Arginine DeiminasesProtein-Arginine Deiminase Type 4

Identifiers

PMID28832760
PMCPMC5561805
OpenAlexW2750085851

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.