ArticlePloS one2017
Peripapillary retinal splitting visualized on OCT in glaucoma and glaucoma suspect patients.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 23 citations in OpenAlex.
- Clinical features of high myopia with optic nerve head prelaminar schisis: Wuhan high myopia study.Eye (London, England) · 2025Article
- Optical coherence tomographic findings of glaucomatous eyes with papillomacular retinoschisis.Eye (London, England) · 2024Article
- Structural Abnormalities in the Papillary and Peripapillary Areas and Corresponding Visual Field Defects in Eyes With Pathologic Myopia.Investigative ophthalmology & visual science · 2022Article
- Performance evaluation of various deep learning based models for effective glaucoma evaluation using optical coherence tomography images.Multimedia tools and applications · 2022Article
- Evaluation of peripapillary atrophy in early open-angle glaucoma using autofluorescence combined with optical coherence tomography.International ophthalmology · 2021Observational
- The Progression of Peripapillary Retinoschisis May Indicate the Progression of Glaucoma.Investigative ophthalmology & visual science · 2021Article
- Factors Determining the Morphology of Peripapillary Retinoschisis.Clinical ophthalmology (Auckland, N.Z.) · 2021Article
- Effect of partial posterior vitreous detachment on spectral-domain optical coherence tomography retinal nerve fibre layer thickness measurements.The British journal of ophthalmology · 2020Article
- Peripapillary Retinoschisis in Glaucoma: Association With Progression and OCT Signs of Müller Cell Involvement.Investigative ophthalmology & visual science · 2018Article
- Peripapillary Retinoschisis as a Manifestation of Ocular Hypotony.Case reports in ophthalmologyArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
purposeTo identify the risk factors for development of peripapillary retinal splitting (schisis) in patients with glaucoma or suspicion of glaucoma.
settingGlaucoma Clinic, Department of Ophthalmology, Northwestern University Feinberg School of Medicine, Chicago, IL.
methodsIn this institutional cross-sectional study, 495 patients (990 eyes) who had undergone spectral-domain optical coherence tomography (OCT Spectralis HRA-OCT, Heidelberg Engineering) optic nerve head (ONH) imaging and did not have identifiable optic nerve pits, pseudopits or coloboma were included. OCT scans were reviewed by two observers.
main outcome measuresPresence of peripapillary retinal splitting identified on OCT raster scans.
resultsEleven of 990 glaucoma and glaucoma suspect eyes (1.1%) of 7 patients (2 females, 5 males, mean age 64.5 ± 9.2 years) had peripapillary retinal splitting. Two of these 11 eyes had extension of the splitting into the macula but none to the fovea. Of these 11 patients, 2 (28.6%) were glaucoma suspects, 3 (42.9%) had primary open-angle glaucoma, 1 (14.3%) had chronic angle-closure glaucoma and 1 (14.3%) had pigmentary glaucoma. 7/11 (63.6%) eyes had vitreous traction to the disc visualized on OCT and 6/11 eyes (54.5%) had beta-zone peripapillary atrophy.
conclusionsWe observed peripapillary retinal splitting in 1.1% of a series of 990 glaucoma and glaucoma-suspect eyes. Evidence of adherent vitreous with traction and peripapillary atrophy was found in a majority of the involved eyes. A comparison to an age and axial length matched cohort is required to determine if this is a condition that is associated with glaucoma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.