ArticlePloS one2017
Dread of uncertain pain: An event-related potential study.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Outcomes of a controlled trial with visiting therapy dog teams on pain in adults in an emergency department.PloS one · 2022Trial
- Approach or Avoidance? The Impact of Pain Expectation on Pain Empathy: An ERP Study.Behavioral sciences (Basel, Switzerland) · 2026Article
- Measures of the psychophysiological response to recurrent anticipatory stress - the influence of neuroticism on heart rhythm and skin resistance.Scientific reports · 2025Article
- EEG Correlates of the Influence of Somatosensory Input, Expectations and Trait-Like Bias on Pain Perception.European journal of pain (London, England) · 2025Article
- Mapping cortical excitability in the human dorsolateral prefrontal cortex.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- PainVision-based evaluation of brain potentials: a novel approach for quantitative pain assessment.Frontiers in bioengineering and biotechnology · 2023Article
- Early Safety Discrimination Under Uncertainty in Trait Anxiety: An Event-Related Potential Study.Frontiers in human neuroscience · 2022Article
- Electrophysiological indices of pain expectation abnormalities in fibromyalgia patients.Frontiers in human neuroscience · 2022Article
- Detecting acute pain signals from human EEG.Journal of neuroscience methods · 2021Article
- Social discounting of pain.Journal of the experimental analysis of behavior · 2020Article
- Understanding sciatica: illness and treatment beliefs in a lumbar radicular pain population. A qualitative interview study.BJGP open · 2019Article
- Anticipation and violated expectation of pain are influenced by trait rumination: An fMRI study.Cognitive, affective & behavioral neuroscience · 2019Article
- Event-related potentials to threat of predictable and unpredictable shock.Psychophysiology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Humans experience more stress about uncertain situations than certain situations. However, the neural mechanism underlying the uncertainty of a negative stimulus has not been determined. In the present study, event-related potential was recorded to examine neural responses during the dread of unpredictable pain. We used a cueing paradigm in which predictable cues were always followed by electric shocks, unpredictable cues by electric shocks at a 50/50 ratio and safe cues by no electric shock. Visual analogue scales following electric shocks were presented to quantify subjective anxiety levels. The behavioral results showed that unpredictable cues evoked high-level anxiety compared with predictable cues in both painful and unpainful stimulation conditions. More importantly, the ERPs results revealed that unpredictable cues elicited a larger P200 at parietal sites than predictable cues. In addition, unpredictable cues evoked larger P200 compared with safe cues at frontal electrodes and compared with predictable cues at parietal electrodes. In addition, larger P3b and LPP were observed during perception of safe cues compared with predictable cues at frontal and central electrodes. The similar P3b effect was also revealed in the left sites. The present study underlined that the uncertain dread of pain was associated with threat appraisal process in pain system. These findings on early event-related potentials were significant for a neural marker and development of therapeutic interventions.
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