Evidence map›Paper›PMID 28832321›Full record

ArticleJournal of psychiatry & neuroscience : JPN2017

Structural alterations in patients with obsessive-compulsive disorder: a surface-based analysis of cortical volume, surface area and thickness.

Oana Georgiana Rus, Tim Jonas Reess, Gerd Wagner, Michael Zaudig, Claus Zimmer, Kathrin Koch

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Oana Georgiana RusFrom the Department of Neuroradiology, Munich, Germany (Rus, Reess, Zimmer, Koch); the TUM-Neuroimaging Center of Klinikum rechts der Isar, Technische Universität München TUM, Munich, Germany (Rus, Reess, Zimmer, Koch); the Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität, Munich, Germany (Rus, Reess, Zimmer, Koch); and the Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany (Zaudig).
Tim Jonas ReessFrom the Department of Neuroradiology, Munich, Germany (Rus, Reess, Zimmer, Koch); the TUM-Neuroimaging Center of Klinikum rechts der Isar, Technische Universität München TUM, Munich, Germany (Rus, Reess, Zimmer, Koch); the Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität, Munich, Germany (Rus, Reess, Zimmer, Koch); and the Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany (Zaudig).
Gerd WagnerFrom the Department of Neuroradiology, Munich, Germany (Rus, Reess, Zimmer, Koch); the TUM-Neuroimaging Center of Klinikum rechts der Isar, Technische Universität München TUM, Munich, Germany (Rus, Reess, Zimmer, Koch); the Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität, Munich, Germany (Rus, Reess, Zimmer, Koch); and the Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany (Zaudig).
Michael ZaudigFrom the Department of Neuroradiology, Munich, Germany (Rus, Reess, Zimmer, Koch); the TUM-Neuroimaging Center of Klinikum rechts der Isar, Technische Universität München TUM, Munich, Germany (Rus, Reess, Zimmer, Koch); the Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität, Munich, Germany (Rus, Reess, Zimmer, Koch); and the Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany (Zaudig).
Claus ZimmerFrom the Department of Neuroradiology, Munich, Germany (Rus, Reess, Zimmer, Koch); the TUM-Neuroimaging Center of Klinikum rechts der Isar, Technische Universität München TUM, Munich, Germany (Rus, Reess, Zimmer, Koch); the Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität, Munich, Germany (Rus, Reess, Zimmer, Koch); and the Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany (Zaudig).
Kathrin KochFrom the Department of Neuroradiology, Munich, Germany (Rus, Reess, Zimmer, Koch); the TUM-Neuroimaging Center of Klinikum rechts der Isar, Technische Universität München TUM, Munich, Germany (Rus, Reess, Zimmer, Koch); the Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität, Munich, Germany (Rus, Reess, Zimmer, Koch); and the Department of Psychiatry and Psychotherapy, Jena University Hospital, Jena, Germany (Zaudig).
Technical University of Munich · DELudwig-Maximilians-Universität München · DEDassault Systèmes (Germany) · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMounting evidence indicates the presence of structural brain alterations in individuals with obsessive-compulsive disorder (OCD). Findings are, however, rather heterogeneous, which may be partly because of differences in methodological approaches or clinical sample characteristics. The aim of the present study was to analyze the whole brain cortical volume, surface area and thickness in a large sample of patients with OCD compared with age- and sex-matched healthy controls.

methodsWe conducted whole brain surface-based analyses of grey matter measures using the automated FreeSurfer software in patients with OCD and matched controls. Group analyses were performed and corrected for multiple testing using Monte Carlo simulations (

resultsWe included 75 patients and 75 controls in our analyses. Patients with OCD showed decreases in both volume and surface area compared with healthy controls in inferior-superior parieto-occipital regions. In addition, the precuneus, posterior cingulate areas, middle frontal and orbitofrontal areas, and middle inferior temporal areas extending to the fusiform gyrus were characterized by a reduced surface area only. There were no differences in grey matter thickness between the groups. LIMITATIONS: The presence of comorbidities, medication usage and the multisymptomatic feature of OCD could have influenced our results to a certain degree.

conclusionOur results suggest decreased grey matter volume and surface area in several key regions in patients with OCD. Parietal regions showed reductions in both volume and surface area, which underlines the potential relevance of these regions for the pathophysiology of the disorder.

Indexed as

AdolescentAdultCerebral CortexComorbidityComputer SimulationFemaleGray MatterHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMiddle AgedMonte Carlo MethodObsessive-Compulsive DisorderOrgan SizePattern Recognition, Automated

Identifiers

PMID28832321
PMCPMC5662461
OpenAlexW2766547898

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.