ArticleJournal of psychiatry & neuroscience : JPN2017
Refinement by integration: aggregated effects of multimodal imaging markers on adult ADHD.
Open access · bronzeAbstract readMulticenter Study
In one paragraph
Article in Journal of psychiatry & neuroscience : JPN, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20citing papers in PubMed
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20 citing papers in PubMed, 51 citations in OpenAlex.
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- Learning Latent Profiles via Cognitive Growth Charting in Psychosis: Design and Rationale for the PRECOGNITION Project.Schizophrenia bulletin open · 2025Article
- Impulsivity in ADHD and Borderline Personality Disorder: A Systematic Review of Gray and White Matter Variations.Journal of clinical medicine · 2024Review
- Parental education and income are linked to offspring cortical brain structure and psychopathology at 9-11 years.JCPP advances · 2024Article
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- Evidence for embracing normative modeling.eLife · 2023Article
- Data-driven multimodal fusion: approaches and applications in psychiatric research.Psychoradiology · 2023Review
- Multimodal fusion analysis of functional, cerebrovascular and structural neuroimaging in healthy aging subjects.Human brain mapping · 2022Article
- The normative modeling framework for computational psychiatry.Nature protocols · 2022Review
- Multimodal brain features at 3 years of age and their relationship with pre-reading measures 1 year later.Frontiers in human neuroscience · 2022Article
- Unimpaired social cognition in adult patients with ADHD: brain volumetric and behavioral results.Social cognitive and affective neuroscience · 2021Article
- Uncovering Statistical Links Between Gene Expression and Structural Connectivity Patterns in the Mouse Brain.Neuroinformatics · 2021Article
- Uncovering neurodevelopmental paths to autism spectrum disorder through an integrated analysis of developmental measures and neural sensitivity to faces.Journal of psychiatry & neuroscience : JPN · 2021Article
- Testing relationships between multimodal modes of brain structural variation and age, sex and polygenic scores for neuroticism in children and adolescents.Translational psychiatry · 2020Article
- Reduced fronto-striatal volume in attention-deficit/hyperactivity disorder in two cohorts across the lifespan.NeuroImage. Clinical · 2020Article
- Individual differencesPsychological medicine · 2020Article
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- Specific patterns of brain alterations underlie distinct clinical profiles in Huntington's disease.NeuroImage. Clinical · 2019Article
- Mapping the Heterogeneous Phenotype of Schizophrenia and Bipolar Disorder Using Normative Models.JAMA psychiatry · 2018Article
- Neural correlates of cognitive function and symptoms in attention-deficit/hyperactivity disorder in adults.NeuroImage. Clinical · 2018Article
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Authors and funding
10 authors at 5 institutions in 2 countries.
Thomas WolfersFrom the Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Wolfers, Onnink, Dammers, Hoogman, Franke); the Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands (Wolfers, Arenas, Hoogman, Zwiers, Franke, Marquand, Beckman); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar, Marquand, Beckmann); the Centre for Functional MRI of the Brain (FMRIB), Oxford University, Oxford, UK (Beckmann); the Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Franke); the Karakter Child and Adolescent Psychiatry University Centre, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar); and the Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK (Marquand).
Alberto Llera ArenasFrom the Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Wolfers, Onnink, Dammers, Hoogman, Franke); the Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands (Wolfers, Arenas, Hoogman, Zwiers, Franke, Marquand, Beckman); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar, Marquand, Beckmann); the Centre for Functional MRI of the Brain (FMRIB), Oxford University, Oxford, UK (Beckmann); the Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Franke); the Karakter Child and Adolescent Psychiatry University Centre, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar); and the Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK (Marquand).
A Marten H OnninkFrom the Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Wolfers, Onnink, Dammers, Hoogman, Franke); the Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands (Wolfers, Arenas, Hoogman, Zwiers, Franke, Marquand, Beckman); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar, Marquand, Beckmann); the Centre for Functional MRI of the Brain (FMRIB), Oxford University, Oxford, UK (Beckmann); the Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Franke); the Karakter Child and Adolescent Psychiatry University Centre, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar); and the Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK (Marquand).
Janneke DammersFrom the Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Wolfers, Onnink, Dammers, Hoogman, Franke); the Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands (Wolfers, Arenas, Hoogman, Zwiers, Franke, Marquand, Beckman); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar, Marquand, Beckmann); the Centre for Functional MRI of the Brain (FMRIB), Oxford University, Oxford, UK (Beckmann); the Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Franke); the Karakter Child and Adolescent Psychiatry University Centre, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar); and the Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK (Marquand).
Martine HoogmanFrom the Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Wolfers, Onnink, Dammers, Hoogman, Franke); the Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands (Wolfers, Arenas, Hoogman, Zwiers, Franke, Marquand, Beckman); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar, Marquand, Beckmann); the Centre for Functional MRI of the Brain (FMRIB), Oxford University, Oxford, UK (Beckmann); the Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Franke); the Karakter Child and Adolescent Psychiatry University Centre, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar); and the Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK (Marquand).
Marcel P ZwiersFrom the Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Wolfers, Onnink, Dammers, Hoogman, Franke); the Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands (Wolfers, Arenas, Hoogman, Zwiers, Franke, Marquand, Beckman); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar, Marquand, Beckmann); the Centre for Functional MRI of the Brain (FMRIB), Oxford University, Oxford, UK (Beckmann); the Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Franke); the Karakter Child and Adolescent Psychiatry University Centre, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar); and the Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK (Marquand).
Jan K BuitelaarFrom the Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Wolfers, Onnink, Dammers, Hoogman, Franke); the Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands (Wolfers, Arenas, Hoogman, Zwiers, Franke, Marquand, Beckman); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar, Marquand, Beckmann); the Centre for Functional MRI of the Brain (FMRIB), Oxford University, Oxford, UK (Beckmann); the Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Franke); the Karakter Child and Adolescent Psychiatry University Centre, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar); and the Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK (Marquand).
Barbara FrankeFrom the Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Wolfers, Onnink, Dammers, Hoogman, Franke); the Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands (Wolfers, Arenas, Hoogman, Zwiers, Franke, Marquand, Beckman); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar, Marquand, Beckmann); the Centre for Functional MRI of the Brain (FMRIB), Oxford University, Oxford, UK (Beckmann); the Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Franke); the Karakter Child and Adolescent Psychiatry University Centre, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar); and the Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK (Marquand).
Andre F MarquandFrom the Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Wolfers, Onnink, Dammers, Hoogman, Franke); the Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands (Wolfers, Arenas, Hoogman, Zwiers, Franke, Marquand, Beckman); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar, Marquand, Beckmann); the Centre for Functional MRI of the Brain (FMRIB), Oxford University, Oxford, UK (Beckmann); the Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Franke); the Karakter Child and Adolescent Psychiatry University Centre, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar); and the Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK (Marquand).
Christian F BeckmannFrom the Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Wolfers, Onnink, Dammers, Hoogman, Franke); the Donders Centre for Cognitive Neuroimaging, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands (Wolfers, Arenas, Hoogman, Zwiers, Franke, Marquand, Beckman); the Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar, Marquand, Beckmann); the Centre for Functional MRI of the Brain (FMRIB), Oxford University, Oxford, UK (Beckmann); the Department of Psychiatry, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands (Franke); the Karakter Child and Adolescent Psychiatry University Centre, Radboud University Medical Centre, Nijmegen, the Netherlands (Buitelaar); and the Department of Neuroimaging, Institute of Psychiatry, King's College London, London, UK (Marquand).
Radboud University Medical Center · NLUniversity of Oxford · GBRadboud University Nijmegen · NLKing's College London · GBWellcome Centre for Integrative Neuroimaging · GB
Funding
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1MNIBIB NIH HHS U54 EB020403
Abstract
backgroundAttention-deficit/hyperactivity disorder (ADHD) is biologically heterogeneous, with different biological predispositions - mediated through developmental processes - converging upon a common clinical phenotype. Brain imaging studies have variably shown altered brain structure, activity and connectivity in children and adults with ADHD. Recent methodological developments allow for the integration of information across imaging modalities, potentially yielding a more coherent view regarding the biology underlying the disorder.
methodsWe analyzed a sample of adults with persistent ADHD and healthy controls using an advanced multimodal linked independent component analysis approach. Diffusion and structural MRI data were fused to form imaging markers reflecting independent components that explain variation across modalities. We included these markers as predictors into logistic regression models on adult ADHD and put those into context with predictions of estimated intelligence, age and sex.
resultsWe included 87 adults with ADHD and 93 controls in our analysis. Participants' courses associated with all imaging markers explained 27.86% of the variance in adult ADHD. No single imaging modality dominated this result. Instead, it was explained by aggregation of relatively small effects across several modalities and markers. One of the top markers for adult ADHD was multimodal and linked to morphological and microstructural effects within anterior temporal brain regions; another was linked to cortical thickness. Several markers were also influenced by estimated intelligence, age and/or sex. LIMITATIONS: Although complex analytical approaches, such as the one applied here, provide insight into otherwise hidden mechanisms, they also increase the complexity of interpretations.
conclusionNo dominant imaging modality or marker characterizes structural brain phenotypes in adults with ADHD, but we can refine our characterization of the disorder by the integration of small effects across modalities.
Indexed as
Magnetic Resonance ImagingAdultAge FactorsAttention Deficit Disorder with HyperactivityBrainCohort StudiesFemaleGray MatterHumansIntelligenceLogistic ModelsMaleMultimodal ImagingOrgan SizeSex Factors
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