ArticlePharmaceutical biology2017
Vasorelaxant properties of Vernonia amygdalina ethanol extract and its possible mechanism.
Article in Pharmaceutical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 38 citations in OpenAlex.
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- Medicinal plants administered to control hypertension in Ethiopia: ethnomedicine, pharmacology, nutraceutical, phytochemistry, toxicology, and policy perspectives.Frontiers in cardiovascular medicine · 2025Review
- Vasorelaxant effects of biochemical constituents of various medicinal plants and their benefits in diabetes.World journal of diabetes · 2024Review
- Computational insights into the inhibitory mechanism of type 2 diabetes mellitus by bioactive components ofFrontiers in pharmacology · 2024Article
- Effect of Ethanolic Extract ofPlants (Basel, Switzerland) · 2023Article
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- Blood pressure-lowering and cardiovascular effects of plumbagin in rats: An insight into the underlying mechanisms.Current research in pharmacology and drug discovery · 2022Article
- Secondary Metabolites of Plants as Modulators of Endothelium Functions.International journal of molecular sciences · 2021Review
- Review of Natural Resources With Vasodilation: Traditional Medicinal Plants, Natural Products, and Their Mechanism and Clinical Efficacy.Frontiers in pharmacology · 2021Review
- In vitro Anticancer Effects ofInternational journal of nanomedicine · 2021Article
- Ethnopharmacological Survey on Treatment of Hypertension by Traditional Healers in Bukavu City, DR Congo.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- Orthogonal Stimulus-Response as a Tool to Formulate Traditional Chinese Medicinal Herbal Combination: - New Scientific-Based TCM Herbal Formulating Method.Journal of pharmacopuncture · 2018Article
- Overview of the Microenvironment of Vasculature in Vascular Tone Regulation.International journal of molecular sciences · 2018Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
contextVernonia amygdalina Del. (VA) (Asteraceae) is commonly used to treat hypertension in Malaysia.
objectiveThis study investigates the vasorelaxant mechanism of VA ethanol extract (VAE) and analyzes its tri-step FTIR spectroscopy fingerprint. MATERIALS AND
methodsDried VA leaves were extracted with ethanol through maceration and concentrated using rotary evaporator before freeze-dried. The vasorelaxant activity and the underlying mechanisms of VAE using the cumulative concentration (0.01-2.55 mg/mL at 20-min intervals) were evaluated on aortic rings isolated from Sprague Dawley rats in the presence of antagonists.
resultsThe tri-step FTIR spectroscopy showed that VAE contains alkaloids, flavonoids, and saponins. VAE caused the relaxation of pre-contracted aortic rings in the presence and absence of endothelium with EC
conclusionsThe vasorelaxation effect of VAE involves upregulation of NO/cGMP and PGI
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