Evidence map›Paper›PMID 28832021›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018

Failure to Inactivate Nuclear GSK3β by Ser

Tina M Thornton, Brendan Hare, Sandra Colié, William W Pendlebury, Angel R Nebreda, William Falls, Diane M Jaworski, Mercedes Rincon

Open access · bronzeAbstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.4field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Trial
  2. Article
  3. Neurobiology of stress · 2025
    Review
  4. Review
  5. GSK3β Inhibition by Phosphorylation at SerInternational journal of molecular sciences · 2022
    Article
  6. Article
  7. Article
  8. Regulation of GSK3β by SerMolecular neurobiology · 2021
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Tina M ThorntonDepartment of Medicine/Immunobiology, University of Vermont, Burlington, VT, USA.
Brendan HareDepartment of Psychology, University of Vermont, Burlington, VT, USA.
Sandra ColiéInstitute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Barcelona, Spain.
William W PendleburyDepartment of Pathology, University of Vermont, Burlington, VT, USA.
Angel R NebredaInstitute for Research in Biomedicine (IRB Barcelona), Barcelona Institute of Science and Technology, Barcelona, Spain.
William FallsDepartment of Psychology, University of Vermont, Burlington, VT, USA.
Diane M JaworskiDepartment of Neurological Sciences, University of Vermont, Burlington, VT, USA.
Mercedes RinconDepartment of Medicine/Immunobiology, University of Vermont, Burlington, VT, USA.
University of Vermont · USInstitució Catalana de Recerca i Estudis Avançats · ESInstitute for Research in Biomedicine · ES

Funding

VERMONT IMMUNOBIOLOIGY/ INFECTIOUS DISEASES CENTERP20RR021905 · NCRR · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI HILL, JACK · 2006 to 2011
$14.5M
Vermont Immunology/Infectious Diseases CenterP30GM118228 · NIGMS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI BUDD, RALPH C · 2016 to 2021
$6.8M
P53 and cell cycle checkpoint by p38 MAP kinaseR01AI051454 · NIAID · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI RINCON, MERCEDES · 2003 to 2019
$4.9M
NCRR NIH HHS P20 RR021905NIAID NIH HHS R01 AI051454NIGMS NIH HHS P30 GM118228
6 · The paper itself

Abstract

GSK3β plays an essential role in promoting cell death and is emerging as a potential target for neurological diseases. Understanding the mechanisms that control neuronal GSK3β is critical. A ubiquitous mechanism to repress GSK3β involves Akt-mediated phosphorylation of Ser

Indexed as

AnimalsBehavior, AnimalCell DeathCerebral CortexFearFemaleGlycogen Synthase Kinase 3 betaHippocampusMaleMiceNeuronsp38 Mitogen-Activated Protein KinasesPhosphorylationPhosphoserineGlycogen Synthase Kinase 3 betaGsk3b protein, mousep38 Mitogen-Activated Protein KinasesPhosphoserine

Identifiers

PMID28832021
PMCPMC5729567
OpenAlexW2749227573

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.