ReviewActa orthopaedica2017
Biological treatment of the knee with platelet-rich plasma or bone marrow aspirate concentrates.
Review in Acta orthopaedica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04711551 (Patients-reported Outcome Measures), which is not on this map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Patients-reported Outcome Measures (PROMs), Clinical Objective and Biomolecular Assessment for the Monitoring of Patients Undergoing Regenerative Medicine Treatments with Orthobiologics
Who cites it
17 citing papers in PubMed.
- A specific protocol of autologous bone marrow concentrate and platelet products versus exercise therapy for symptomatic knee osteoarthritis: a randomized controlled trial with 2 year follow-up.Journal of translational medicine · 2018Trial
- Exploring the Efficacy of Biologics in Knee Osteoarthritis: Ultrasound Evaluation of Cartilage Regeneration Effects.Indian journal of orthopaedics · 2024Article
- Anterior Knee Pain: State of the Art.Sports medicine - open · 2022Review
- Bone marrow aspirate concentrate versus platelet-rich plasma for treating knee osteoarthritis: a one-year non-randomized retrospective comparative study.BMC musculoskeletal disorders · 2022Article
- Combined Bone Marrow Aspirate and Platelet-Rich Plasma for Cartilage Repair: Two-Year Clinical Results.Cartilage · 2021Article
- Arthroscopic Fixation of Knee Femoral Condyle Osteochondritis Dissecans Fragment With Bone Marrow Aspirate Concentrate.Arthroscopy techniques · 2021Article
- Platelet-rich plasmaWorld journal of stem cells · 2021Review
- The platelet-rich plasma and mesenchymal stem cell milieu: A review of therapeutic effects on bone healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- MULTI-LIGAMENT KNEE RECONSTRUCTION AND NOVEL MENISCUS RADIAL REPAIR TECHNIQUE, WITH RETURN TO OLYMPIC LEVEL SKIING: A CASE REPORT.International journal of sports physical therapy · 2020Article
- Cell Therapy-a Basic Science Primer for the Sports Medicine Clinician.Current reviews in musculoskeletal medicine · 2019Review
- Assessing clinical implications and perspectives of the pathophysiological effects of erythrocytes and plasma free hemoglobin in autologous biologics for use in musculoskeletal regenerative medicine therapies. A review.Regenerative therapy · 2019Review
- Stem Cell-Infused Anterior Cruciate Ligament Reconstruction.Arthroscopy techniques · 2019Article
- Arthroscopy Association of Canada Position Statement on Intra-articular Injections for Knee Osteoarthritis.Orthopaedic journal of sports medicine · 2019Article
- Bone Marrow Aspirate Concentrate for the Treatment of Avascular Meniscus Tears in a One-Step Procedure-Evaluation of an In Vivo Model.International journal of molecular sciences · 2019Article
- [Operative treatment of cartilage lesions].Der Orthopade · 2018Article
- Patellofemoral Cartilage Repair.Current reviews in musculoskeletal medicine · 2018Review
- Facilitated recruitment of mesenchymal stromal cells by bone marrow concentrate and platelet rich plasma.PloS one · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
- Knee pathologies including focal cartilage injuries, osteoarthritis (OA), and ligament injuries are common. The poor regeneration and healing potential of cartilage has led to the search for other treatment modalities with improved healing capacity. Furthermore, with an increasing elderly population that desires to remain active, the burden of knee pathologies is expected to increase. Increased sports participation and the desire to return to activities faster is also demanding more effective and minimally invasive treatment options. Thus, the use of biologic agents in the treatment of knee pathologies has emerged as a potential option. Despite the increasing use of biologic agents for knee pathology, there are conflicting results on the efficacy of these products. Furthermore, strong data supporting the optimal preparation methods and composition for widely used biologic agents, such as platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC), largely remain absent from the literature. This review presents the literature on the most commonly employed biologic agents for the different knee pathologies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.