ArticleLa Radiologia medica2017
Relationship between magnetic resonance imaging findings, radiological grading, psychological distress and pain in patients with symptomatic knee osteoarthritis.
Article in La Radiologia medica, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Clinical utility of Dual Energy Computed Tomography in gout: current concepts and applications.Acta bio-medica : Atenei Parmensis · 2020Pooled it
- Psychological stress and gut microbiota regulation of osteoarthritis progression: mechanisms and therapeutic strategies.Frontiers in microbiology · 2026Review
- Imaging-based measures of synovitis in knee osteoarthritis: A scoping review and narrative synthesis.Osteoarthritis and cartilage open · 2025Review
- Infrapatellar fat pad as a source of biomarkers and therapeutic target for knee osteoarthritis.Arthritis research & therapy · 2025Review
- Comparison of MRI Osteoarthritis Knee Score with Clinico-Radiological Grading.The Indian journal of radiology & imaging · 2025Article
- Association between infrapatellar fat pad ultrasound elasticity and anterior knee pain in patients with knee osteoarthritis.Scientific reports · 2023Article
- Outcome analysis of infrapatellar fat pad partial resection or preservation in patients with anterior cruciate ligament reconstruction.Scientific reports · 2023Article
- Evaluation of mindfulness based stress reduction in symptomatic knee or hip osteoarthritis patients: a pilot randomized controlled trial.BMC rheumatology · 2022Article
- Association between Chronic Knee Pain and Psychological Stress in Those over 50 Years of Age: A Nationwide Cross-Sectional Study Based on the Sixth Korea National Health and Nutrition Examination Survey (KNHANES 2013-2015).International journal of environmental research and public health · 2021Article
- The joint involvement in adult onset Still's disease is characterised by a peculiar magnetic resonance imaging and a specific transcriptomic profile.Scientific reports · 2021Observational
- Flexibility of infrapatellar fat pad affecting anterior knee pain 6 months after anterior cruciate ligament reconstruction with hamstring autograft.Scientific reports · 2020Article
- The alarmins S100A8 and S100A9 mediate acute pain in experimental synovitis.Arthritis research & therapy · 2020Article
- Diagnostic and interventional management of infective spine diseases.Acta bio-medica : Atenei Parmensis · 2020Review
- Diagnostic and interventional radiology: an update.Acta bio-medica : Atenei Parmensis · 2020Article
- Anterior chest wall non-traumatic diseases: a road map for the radiologist.Acta bio-medica : Atenei Parmensis · 2020Review
- Advanced diagnostic imaging and intervention in tendon diseases.Acta bio-medica : Atenei Parmensis · 2020Review
- Diagnostic and interventional radiology fundamentals of synovial pathology.Acta bio-medica : Atenei Parmensis · 2020Review
- New advances in MRI diagnosis of degenerative osteoarthropathy of the peripheral joints.La Radiologia medica · 2019Review
- Magnetic Resonance Imaging in degenerative disease of the lumbar spine: Fat Saturation technique and contrast medium.Acta bio-medica : Atenei Parmensis · 2018Article
- Developments in the management of bone metastases with interventional radiology.Acta bio-medica : Atenei Parmensis · 2018Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSynovial hypertrophy, synovial effusions, and abnormalities in the subchondral bone play a key role in the pathogenesis of osteoarthritis (OA) and are associated with pain. Understanding and careful clinical assessment together with better imaging such as magnetic resonance imaging (MRI) of the knee may improve treatment strategies. The aim of this cross-sectional study was to investigate the associations between the structural findings on MRI (bone marrow lesions [BMLs], synovitis, cartilage defects, meniscal lesions), X-ray examination (Kellgren and Lawrence [K/L] grade), and psychological aspects with pain in patients with knee osteoarthritis (KOA).
methodsIn this study, patients with symptomatic KOA were included. Knee radiographs were acquired and scored according to the K/L score. MRI was performed with a 1.5 T whole-body scanner; the presence of the following alterations was collected: BMLs, infrapatellar fat pad (IFP) synovitis, condral defects, and meniscal tears. Knee pain was assessed with Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscale. The Mental Component Summary Scale Score (MCS) of the Medical Outcomes Study Short-Form 36 Health Survey (SF-36) questionnaire was used to evaluate psychological impact.
resultsBMLs were detected in 57 (38.3%) subjects of 149 participants (aged 51-81 years, female 75.8%). Cartilage defects were found in 91.9% of patients, IFP synovitis in 37.5%, meniscal lesions in 34.9%. In multiple regression analyses, WOMAC knee pain was significantly associated with the volume of the BMLs (p = 0.0001), IFP synovitis (p = 0.0036), and SF-36 MCS (p = 0.0001), but not with K/L grades, meniscal lesion score, cartilage defect, sex, age, educational level, disease duration and BMI.
conclusionIn symptomatic KOA patients, MRI features, such as larger BMLs, IFP synovitis, and high levels of psychological distress, are associated with greater knee pain. Confirmation of these findings in the prospective studies of KOA is needed.
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