Evidence map›Paper›PMID 28831749›Full record

ArticleJournal of neurovirology2017

PML-IRIS in an HIV-2-infected patient presenting as Bell's palsy.

Fabian Sierra Morales, Carlos Illingworth, Kathie Lin, Ivia Rivera Agosto, Chloé Powell, Jacob A Sloane, Igor J Koralnik

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurovirology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Brainstem progressive multifocal leukoencephalopathy.European journal of neurology · 2021
    Article
  3. Host-Immune Interactions in JC Virus Reactivation and Development of Progressive Multifocal Leukoencephalopathy (PML).Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Fabian Sierra MoralesSection of Neuro-Infectious Diseases, Rush University Medical Center, 1725 W. Harrison Street, Suite 1106, Chicago, IL, 60612, USA.
Carlos IllingworthDepartment of Neurology, Hahnemann University Hospital, Philadelphia, PA, USA.
Kathie LinDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Ivia Rivera AgostoDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Chloé PowellDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Jacob A SloaneDepartment of Neurology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Igor J KoralnikSection of Neuro-Infectious Diseases, Rush University Medical Center, 1725 W. Harrison Street, Suite 1106, Chicago, IL, 60612, USA. igor_koralnik@rush.edu.
Beth Israel Deaconess Medical Center · USRush University Medical Center · USHahnemann University Hospital · US

Funding

Role of Inflammation in Progressive Multifocal LeukoencephalopathyR01NS047029 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI KORALNIK, IGOR J. · 2004 to 2018
$6.4M
Pathogenesis of a JC Virus Variant in Pyramidal NeuronsR01NS074995 · NINDS · RUSH UNIVERSITY MEDICAL CENTER · PI KORALNIK, IGOR J. · 2012 to 2016
$1.8M
NINDS NIH HHS R01 NS047029NINDS NIH HHS R01 NS074995
6 · The paper itself

Abstract

We present the case of an HIV-2-infected patient who developed progressive multifocal leukoencephalopathy (PML) in the setting of immune reconstitution inflammatory syndrome (IRIS) presenting as Bell's palsy. The brain MRI showed a single lesion in the facial colliculus considered initially to be ischemic in nature. This case report should alert clinicians that PML can occur in the setting of HIV-2 infection. It also illustrates the difficulty of establishing the diagnosis of PML.

Indexed as

HIV-2AgedBell PalsyHIV InfectionsHumansImmune Reconstitution Inflammatory SyndromeLeukoencephalopathy, Progressive MultifocalMaleBell’s palsyHIV-2Immune reconstitution inflammatory syndromeJC virusProgressive multifocal leukoencephalopathy

Identifiers

PMID28831749
PMCPMC5718171
OpenAlexW2745322602

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.