Evidence map›Paper›PMID 28831739›Full record

ArticleAnnals of nuclear medicine2017

Patterns of uptake of prostate-specific membrane antigen (PSMA)-targeted

Rudolf A Werner, Sara Sheikhbahaei, Krystyna M Jones, Mehrbod S Javadi, Lilja B Solnes, Ashley E Ross, Mohamad E Allaf, Kenneth J Pienta, Constantin Lapa, Andreas K Buck and 4 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of nuclear medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Intraindividual comparison of [EJNMMI research · 2021
    Article
  11. Intra-patient comparison of physiologicCancer imaging : the official publication of the International Cancer Imaging Society · 2021
    Article
  12. Article
  13. Article
  14. Article
  15. Dynamic patterns of [European journal of nuclear medicine and molecular imaging · 2020
    Article
  16. Theranostics · 2020
    Review
  17. European journal of nuclear medicine and molecular imaging · 2020
    Article
  18. Review
  19. Article
  20. Novel Structured Reporting Systems for Theranostic Radiotracers.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Rudolf A WernerDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St., Baltimore, MD, 21287, USA.
Sara SheikhbahaeiDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St., Baltimore, MD, 21287, USA.
Krystyna M JonesDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St., Baltimore, MD, 21287, USA.
Mehrbod S JavadiDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St., Baltimore, MD, 21287, USA.
Lilja B SolnesDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St., Baltimore, MD, 21287, USA.
Ashley E RossTexas Urology Specialists, Dallas, TX, USA.
Mohamad E AllafThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kenneth J PientaThe James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Constantin LapaDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Andreas K BuckDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Takahiro HiguchiDepartment of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany.
Martin G PomperDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St., Baltimore, MD, 21287, USA.
Michael A GorinDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St., Baltimore, MD, 21287, USA.
Steven P RoweDivision of Nuclear Medicine and Molecular Imaging, The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, 601 N. Caroline St., Baltimore, MD, 21287, USA. srowe8@jhmi.edu.
Johns Hopkins Medicine · USUniversitätsklinikum Würzburg · DEJohns Hopkins University · USDermatology Specialists · US

Funding

PSMA-based Cancer Imaging AgentsR01CA134675 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI POMPER, MARTIN G · 2009 to 2025
$6.2M
PSMA Directed Imaging of Prostate Cancer Focus on Androgen Receptor DynamicsU01CA183031 · NCI · JOHNS HOPKINS UNIVERSITY · PI DEWEESE, THEODORE L, POMPER, MARTIN G · 2015 to 2017
$1.2M
NCI NIH HHS R01 CA134675NCI NIH HHS U01 CA183031
6 · The paper itself

Abstract

objectiveRadiotracers targeting prostate-specific membrane antigen (PSMA) have increasingly been recognized as showing uptake in a number of normal structures, anatomic variants, and non-prostate-cancer pathologies. We aimed to explore the frequency and degree of uptake in peripheral ganglia in patients undergoing PET with the PSMA-targeted agent

methodsA total of 98 patients who underwent

resultsOverall, 95 of 98 (96.9%) patients demonstrated uptake in at least one of the evaluated peripheral ganglia. With regard to the PCa cohort, the most frequent sites of radiotracer accumulation were lumbar ganglia (55/76, 72.4%), followed by the cervical ganglia (51/76, 67.1%). Bilateral uptake was found in the majority of cases [lumbar 44/55 (80%) and cervical 30/51 (58.8%)]. Additionally, discernible radiotracer uptake was recorded in 50/76 (65.8%) of the analyzed stellate ganglia and in 45/76 (59.2%) of the celiac ganglia, whereas only 5/76 (6.6%) of the sacral ganglia demonstrated

conclusionAs PSMA-targeted agents become more widely disseminated, the patterns of uptake in structures that are not directly relevant to patients' cancers must be understood. This is the first systematic evaluation of the uptake of

Indexed as

AgedAged, 80 and overAntigens, SurfaceBiological TransportCarcinoma, Renal CellGangliaGlutamate Carboxypeptidase IIHumansImage Processing, Computer-AssistedKidney NeoplasmsLysineMaleMiddle AgedPositron Emission Tomography Computed TomographyProstatic NeoplasmsRetrospective Studies2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acidAntigens, SurfaceFOLH1 protein, humanGlutamate Carboxypeptidase IILysineUrea18F-DCFPyLGangliaImaging pitfallsProstate cancerPSMA

Identifiers

PMID28831739
PMCPMC5651702
OpenAlexW2750060964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.