ArticleThe journal of headache and pain2017
Screening of genetic variants in ADCYAP1R1, MME and 14q21 in a Swedish cluster headache cohort.
Article in The journal of headache and pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Family History of Cluster Headache: A Systematic Review.JAMA neurology · 2020Pooled it
- Targeting PACAP: Beyond Migraine to Cluster, Menstrual, and Post-traumatic Headaches.Advances in therapy · 2025Review
- Genetics of migraine: where are we now?The journal of headache and pain · 2023Review
- Genetic overlap between temporomandibular disorders and primary headaches: A systematic review.The Japanese dental science review · 2022Review
- Evidence That HFE H63D Variant Is a Potential Disease Modifier in Cluster Headache.Journal of molecular neuroscience : MN · 2022Article
- Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache.Annals of neurology · 2021Article
- Genome-Wide Association Study Identifies Risk Loci for Cluster Headache.Annals of neurology · 2021Article
- Cluster headache and TACs: state of the art.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2020Review
- Analysis of HCRTR2, GNB3, and ADH4 Gene Polymorphisms in a Southeastern European Caucasian Cluster Headache Population.Journal of molecular neuroscience : MN · 2020Article
- Calcitonin Gene-Related Peptide (CGRP) and Cluster Headache.Brain sciences · 2020Review
- Anoctamin 3: A Possible Link between Cluster Headache and CaBrain sciences · 2019Article
- PACAP in hypothalamic regulation of sleep and circadian rhythm: importance for headache.The journal of headache and pain · 2018Review
- Pain sensitivity genes as therapeutic targets in knee osteoarthritis: A comprehensive analysis.Molecular painArticle
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe have genotyped a Swedish cluster headache case-control population for three genetic variants representing the most significant markers identified in a recently published genome wide association study on cluster headache. The genetic variants were two common polymorphisms; rs12668955 in ADCYAP1R1 (adenylate cyclase activating polypeptide 1 receptor type 1), rs1006417, an intergenic variant on chromosome 14q21 and one rare mutation, rs147564881, in MME (membrane metalloendopeptidase).
resultsWe screened 542 cluster headache patients and 581 controls using TaqMan real-time PCR on a 7500 fast cycler, and pyrosequencing on a PSQ 96 System. Statistical analysis for genotype and allele association showed that neither of the two common variants, rs12668955 and rs1006417 were associated with cluster headache. The MME mutation was investigated with pyrosequencing in patients, of whom all were wild type.
conclusionIn conclusion rs12668955 and rs1006417 do not impact the risk of developing cluster headache in the Swedish population. Also, rs147564881 does not seem to be enriched within the Swedish cluster headache patient group.
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