ArticleMolecular diversity2017
Cheminformatic characterization of natural products from Panama.
Article in Molecular diversity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Update and ADMET Profile of the Latin American Natural Product Database: LANaPDB.Molecular informatics · 2025Article
- Article
- Latin American Natural Product Database (LANaPDB): An Update.Journal of chemical information and modeling · 2024Article
- Navigating the Chemical Space of ENR Inhibitors: A Comprehensive Analysis.Antibiotics (Basel, Switzerland) · 2024Article
- Navigating the Chemical Space and Chemical Multiverse of a Unified Latin American Natural Product Database: LANaPDB.Pharmaceuticals (Basel, Switzerland) · 2023Article
- On the importance for drug discovery of a transnational Latin American database of natural compound structures.Frontiers in pharmacology · 2023Article
- Progress and Impact of Latin American Natural Product Databases.Biomolecules · 2022Review
- Latin American databases of natural products: biodiversity and drug discovery against SARS-CoV-2.RSC advances · 2021Article
- Cheminformatics in Natural Product-based Drug Discovery.Molecular informatics · 2020Review
- Cheminformatics to Characterize Pharmacologically Active Natural Products.Biomolecules · 2020Review
- Towards a unified Latin American Natural Products Database: LANaPD.Future science OA · 2020Review
- Exploring the chemical space of peptides for drug discovery: a focus on linear and cyclic penta-peptides.Molecular diversity · 2018Article
- Chemoinformatics: a perspective from an academic setting in Latin America.Molecular diversity · 2018Article
- Inhibitors of DNA Methyltransferases From Natural Sources: A Computational Perspective.Frontiers in pharmacology · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
In this work, we discuss the characterization and diversity analysis of 354 natural products (NPs) from Panama, systematically analyzed for the first time. The in-house database was compared to NPs from Brazil, compounds from Traditional Chinese Medicine, natural and semisynthetic collections used in high-throughput screening, and compounds from ChEMBL. An analysis of the "global diversity" was conducted using molecular properties of pharmaceutical interest, three molecular fingerprints of different design, molecular scaffolds, and molecular complexity. The global diversity was visualized using consensus diversity plots that revealed that the secondary metabolites in the Panamanian flora have a large scaffold diversity as compared to other composite databases and also have several unique scaffolds. The large scaffold diversity is in agreement with the broad range of biological activities that this collection of NPs from Panama has shown. This study also provided further quantitative evidence of the large structural complexity of NPs. The results obtained in this study support that NPs from Panama are promising candidates to identify selective molecules and are suitable sources of compounds for virtual screening campaigns.
Indexed as
Identifiers
28831697What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.