Evidence map›Paper›PMID 28831695›Full record

Trial reportJournal of pharmacokinetics and pharmacodynamics2017

Evaluation of pharmacokinetic model designs for subcutaneous infusion of insulin aspart.

Erin J Mansell, Signe Schmidt, Paul D Docherty, Kirsten Nørgaard, John B Jørgensen, Henrik Madsen

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of pharmacokinetics and pharmacodynamics, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Erin J MansellCentre for Bioengineering, University of Canterbury, Private Bag 4800, Christchurch, 8140, New Zealand.
Signe SchmidtDepartment of Endocrinology, Hvidovre University Hospital, Kettegård Allé 30, 2650, Hvidovre, Denmark.
Paul D DochertyCentre for Bioengineering, University of Canterbury, Private Bag 4800, Christchurch, 8140, New Zealand. paul.docherty@canterbury.ac.nz.ORCID http://orcid.org/0000-0003-1661-2573
Kirsten NørgaardDepartment of Endocrinology, Hvidovre University Hospital, Kettegård Allé 30, 2650, Hvidovre, Denmark.ORCID http://orcid.org/0000-0003-1620-8271
John B JørgensenDepartment of Applied Mathematics and Computer Science, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark.ORCID http://orcid.org/0000-0001-9799-2808
Henrik MadsenDepartment of Applied Mathematics and Computer Science, Technical University of Denmark, 2800, Kgs. Lyngby, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Effective mathematical modelling of continuous subcutaneous infusion pharmacokinetics should aid understanding and control in insulin therapy. Thorough analysis of candidate model performance is important for selecting the appropriate models. Eight candidate models for insulin pharmacokinetics included a range of modelled behaviours, parameters and complexity. The models were compared using clinical data from subjects with type 1 diabetes with continuous subcutaneous insulin infusion. Performance of the models was compared through several analyses: R

Indexed as

Models, CardiovascularAdultDiabetes Mellitus, Type 1FemaleHumansInfusions, SubcutaneousInsulin AspartMaleMiddle AgedYoung AdultInsulin AspartContinuous subcutaneous insulin infusionGoodness of fitParameter identificationPharmacokinetic modellingPractical identifiabilityType 1 diabetes

Identifiers

PMID28831695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.